In this study, we characterized the role of delta-1 and delta-2 opioid receptors in the ventromedial medulla (VMM) in the modulation of thermal nociception. Male Sprague-Dawley rats were prepared with an intracerebral guide cannula aimed at the nucleus raphe magnus or nucleus reticularis gigantocellularis pars alpha. Microinjection of the delta-1 opioid receptor agonist [D-Pen2,D-Pen5]enkephali...

To determine the effects of different levels of glucose intake on glucose homeostasis, gluconeogenesis, body composition, and tumor growth, we gave 8 days of total parenteral feeding of a defined liquid formula diet to groups of Buffalo rats, with and without a transplantable Morris 7777 hepatoma. The level of glucose intake was held at levels which ranged from 0 to 9.5 g/100 body weight per da...

Using a magnetically aligned liquid crystal mixture containing a novel Se-labelled dimer and the difluoroterphenyl dimer DTC5C7, the twist-bend nematic phase (Ntb) was studied by the resonant scattering of hard X-rays and by conventional small and wide-angle X-ray scattering (SAXS, WAXS). Resonant diffraction spots indicated a helix with a 9-12 nm pitch in the Ntb phase and an unprecedentedly h...

OBJECTIVE To examine whether near-term births (NTB) and small-for-gestational-age (SGA) infants are at high risk for childhood learning-related problems and poor adult educational attainment, and whether poverty amplifies the adverse effects of NTB and SGA on those outcomes. METHODS A randomly selected birth cohort (n = 1,619) was followed into adulthood. IQ and learning abilities were measur...

This paper investigates the effect of economic integration on the ability of firms to maintain a collusive understanding about staying out of each other’s markets. The paper distinguishes among different types of trade costs: ad valorem, unit, fixed. It is shown that for a sufficient reduction of ad valorem trade costs, a cartel supported by collusion on either quantities or prices will be weak...

(NTB) algorithm is proposed for human activity recognition in videos. The proposed NTB algorithm models the entire scene as an error-free network. In this network, each node corresponds to a patch of the scene and each edge represents the activity correlation between the corresponding patches. Based on this network, we further model people in the scene as packages while human activities can be ...

A six-coordinate manganese (II) complex with the tripod ligand tris(2-benzimidazolylmethyl)amine (ntb), with composition [Mn(ntb) (4-hydroxycinnamate)](4-hydroxycinnamate) · (DMF)0.5 · (H2O)3, was synthesized and characterized by elemental and thermal analyses, electrical conductivity, IR, and UV/vis spectral measurements. The crystal structure of the complex has been determined by the single-c...

The NTB-VPg polyprotein from tomato ringspot virus is an integral membrane replication protein associated with endoplasmic reticulum membranes. A signal peptidase (SPase) cleavage was previously detected in the C-terminal region of NTB-VPg downstream of a 14 amino acid (aa)-long hydrophobic region (termed TM2). However, the exact location of the cleavage site was not determined. Using in vitro ...

The anabolic effects of exogenous neutral protamine hagedorn insulin on tumor-bearing (TB) and non-tumor-bearing (NTB) rats were examined. Exogenous insulin (2 units/100 g/day) produced similar hypoglycemia in TB and NTB rats. Food intake and body weight gain were significantly increased by insulin in NTB rats. In TB rats in an early stage of cachexia, insulin increased food intake and host wei...

a r t i c l e i n f o JEL classification: D21 D43 D44 D45 Keywords: Patent licensing Insider Asymmetric information Per unit royalty Ad valorem royalty We study an inside patent holder's optimal licensing policy when it has imperfect information about the value of the patent to its rival. The patent holder can choose any two-part licensing fee with either per unit or ad valorem royalties. We de...