The selection of significant components in a sparse vector, directly observed with i.i.d. observational noise, typically proceeds by thresholding the observations. The objective in this paper is to choose the threshold that minimizes the risk (expected squared prediction error) of the estimator with respect to the noise-free sparse vector. The risk as a function of the model size (or, equivalen...

background: cytomegalovirus (cmv), a problematic virus in solid organ transplant recipients (sotr) such as liver, can worsen overall mortality and transplant outcome, so its prevention and treatment is a key of success in such patients. this study is aimed to compare the efficacy of ganciclovir (gcv) and valganciclovir (vgc) for prevention and treatment of infection with cmv. materials and meth...

The pharmacokinetics of an orally administered valine ester of ganciclovir (GCV), valganciclovir (VGC), were studied. These were compared to the pharmacokinetics of oral and intravenous GCV. Twenty-eight liver transplant recipients received, in an open-label random order with a 3- to 7-day washout, each of the following: 1 g of oral GCV three times a day; 450 mg of VGC per os (p.o.) once a day ...

In some cases of regression modeling, it is very common to find a repeating pattern. To model this, course, the approach used must be in accordance with characteristics data. The Fourier series one proposed approaches, because has advantages modeling relationship patterns that tend repeat, such as cosine sine waves. subset nonparametric regression, which good flexibility modeling. this study, w...

BACKGROUND Intraocular cytomegalovirus (CMV) infections, including endotheliitis and retinitis, have been reported to threaten the host's vision. These infections have been treated with systemic or intravitreal GCV injection. Intracameral GCV injection can be an effective treatment option that avoids systemic side effects. The cytotoxic effect of ganciclovir (GCV) on cultured human corneal endo...

The tting of a thin plate smoothing spline to noisy data using the method of minimizing the Generalized Cross Validation (GCV) function is computationally intensive involving the repeated solution of sets of linear systems of equations as part of a minimization routine. In the case of a data set of more than a few hundred points, implementation on a workstation can become unrealistic and it is ...

BACKGROUND The electroencephalography (EEG) is an attractive and a simple technique to measure the brain activity. It is attractive due its excellent temporal resolution and simple due to its non-invasiveness and sensor design. However, the spatial resolution of EEG is reduced due to the low conducting skull. In this paper, we compute the potential distribution over the closed surface covering ...

Noisy data are often fitted using a smoothing parameter, controling the importance of two objectives that are opposite to a certain extent. One of these two is smoothness and the other is closeness to the input data. The optimal value of this paramater minimizes the error of the result (as compared to the unknown, exact data), usually expressed in the L2 norm. This optimum cannot be found exact...

Gene conversion (GCV), a mechanism mediated by activation-induced cytidine deaminase (AID) is well established as a mechanism of immunoglobulin diversification in a few species. However, definitive evidence of GCV-like events in human immunoglobulin genes is scarce. The lack of evidence of GCV in human rearranged immunoglobulin gene sequences is puzzling given the presence of highly similar ger...

OBJECTIVES To evaluate in vivo anatomical relationships between the coronary sinus-great cardiac vein (CS-GCV), the mitral valve annulus (MVA), and left circumflex coronary artery (LCX) with cardiovascular magnetic resonance. BACKGROUND The CS-GCV has become an anatomical structure of interest because it provides a way of access to the heart for a number of interventional procedures. Previous...