Laminins regulate diverse cellular functions through interaction with integrins. Two regions of laminins—three laminin globular domains of the a chain (LG1–3) and the carboxyl-terminal tail of the g chain (g-tail)—are required for integrin binding, but it remains unclear how the g-tail contributes to the binding. We determined the crystal structure of the integrin binding fragment of laminin-51...

Laminins regulate diverse cellular functions through interaction with integrins. Two regions of laminins-three laminin globular domains of the α chain (LG1-3) and the carboxyl-terminal tail of the γ chain (γ-tail)-are required for integrin binding, but it remains unclear how the γ-tail contributes to the binding. We determined the crystal structure of the integrin binding fragment of laminin-51...

The WD-repeat domain is a highly conserved recognition module in eukaryotes involved in diverse cellular processes. It is still not well understood how the bottom of a WD-repeat domain recognizes its binding partners. The WD-repeat-containing protein EED is one component of the PRC2 complex that possesses histone methyltransferase activity required for gene repression. Here we report the crysta...

Mitochondria exert an immense amount of cytophysiological functions, but the structural basis of most of these processes is still poorly understood. Here we use cross-linking mass spectrometry to probe the organization of proteins in native mouse heart mitochondria. Our approach provides the largest survey of mitochondrial protein interactions reported so far. In total, we identify 3,322 unique...

Soil organic carbon (SOC) turnover plays a pivotal role in achieving C neutrality, promoting retention and increasing soil fertility. Residue biochemistry texture essentially determine SOC distribution (including CO2 mineralization stock soil) farmland. However, less is known about allocation of residue-C with contrasting the fate under two different textures. This study was conducted 61-day ae...

Two new pre-treatment methods (water-washing/carbonation and carbonation/phosphate stabilisation) of municipal solid waste (MSW) incinerator residues were evaluated by column leaching tests under aerobic conditions and anaerobic conditions (which were changed to aerobic conditions after 10 months). A mixture of bottom ash and fly ash (5:1 ratio) was pre-treated using each method. Shredded incom...

Given an arbitrary n, we consider anisotropic quadratic forms of dimension n over all fields of characteristic = 2 and prove that the height of an n-dimensional excellent form (depending on n only) is the (precise) lower bound of the heights of all forms of dimension n.

An ancient organic residue was collected from the bottom of a Greco-Italian amphora found in the Adriatic Sea and investigated by direct GC and GC-MS analysis. The headspace composition was determined by HS-SPME using: (1) DVB/CAR/PDMS and (2) PDMS/DVB fibres. Higher percentages of benzene derivatives, monoterpenes and other low-molecular aliphatic compounds were obtained by method (1) in contr...

a trial study was carried out to assess the influence of the plant residue management in conjuction with application of different nitrogen sources on wheat yield and components, at the agricultural faculty of shahidchamran university of ahvaz during 2011-2012.the experimental design was splitplot at randomized completed block design arrangement. the main plot were different wheat residue manage...

background: tetracyclines (tcs) are broad-spectrumantibiotics that are widely used in veterinary medicine. thepresence of tcs residues in milk is a public health concern allover the world. objectives:this study aimed to determine tcsresiduals in pasteurized milk marketed by some dairy companiesin tehran from april 2011 to march 2012. methods: 432pasteurized milk samples were purchased from supe...