BACKGROUND Progesterone, via its nuclear receptor (PR), exerts an overall tumorigenic effect on both uterine fibroid (leiomyoma) and breast cancer tissues, whereas the antiprogestin RU486 inhibits growth of these tissues through an unknown mechanism. Here, we determined the interaction between common or cell-specific genome-wide binding sites of PR and mRNA expression in RU486-treated uterine l...

laparoscopically-assisted vaginal hysterectomy (lavh) was performed in fifteen patients without invasive cancer. indications for hysterectomy were myomas, abnormal uterine bleeding unresponsive to hormonal treatment and dilatation and curettage, chronic pelvic pain with first degree uterine prolapse and possible adenomyosis, and dysplasia and ovarian cyst in postmenopausal years. no significant...

OBJECTIVE In previous studies, we have shown a three to four times higher urban incidence of breast cancer and estrogen receptor-positive breast cancers in the Gharbiah Province of Egypt. We investigated the urban-rural incidence differences of gynaecologic malignancies (uterine, ovarian and cervical cancers) to explore if they show the same trend that we found for breast cancer. DESIGN Cance...

STUDY OBJECTIVE The aim was to study the influence of childbearing pattern on the incidence of breast cancer and uterine corpus cancer. DESIGN This was an ecological study of birth cohorts of women. SETTING The study was population based, involving the whole of Norway. PARTICIPANTS The participants were Norwegian women born between 1890 and 1944. MEASUREMENTS AND MAIN RESULTS Age specif...

BACKGROUND Uterine cancer is the fourth most common cancer in women in the UK, with approximately 7700 new diagnoses and 1700 deaths annually. AIM To identify and quantify features of uterine cancer in primary care. DESIGN AND SETTING Case-control study using electronic primary care records in primary care in the UK. METHOD Putative features of uterine cancer were identified in the year b...

The American Cancer Society estimates that 60,050 cases of endometrial cancer will be diagnosed in 2016 and 10,470 die from during 2016. Since 1988, incidence rates have increased by 1.3 per cent year for women under 50 1.9 year. In age older, uterine cancers are usually treated with surgery, radiation, hormones, and/or chemotherapy. Uterine is the most common form gynecologic cancer. Surgery m...

IMPORTANCE Myomectomy, the excision of uterine leiomyoma, is now commonly performed via minimally invasive surgery. Electric power morcellation, or fragmentation of the leiomyoma with a mechanical device, may be used to facilitate extraction of the leiomyoma. OBJECTIVE To analyze the prevalence of underlying cancer and precancerous changes in women who underwent myomectomy with and without el...

Haploinsufficient inactivating phosphatase and tensin homolog (Pten) mutations cause Cowden syndrome, an autosomal dominant risk genotype for hormone dependent reproductive cancers. As androgen actions mediated via the androgen receptor (AR) supports uterine growth and may modify uterine cancer risk, we hypothesized that a functional AR may increase PTEN inactivation induced uterine cancer. To ...

OBJECTIVES The purpose of this study is to statistically compare the mean ages of the patients with gynecologic cancer in our hospital during the 2000-2009 interval. MATERIAL AND METHODS The data was collected from the Histopathology Exams (HPE) registers. RESULTS Gynecologic cancer was discovered in 1244 cases: 731 cervical cancers, 392 uterine cancers, 82 ovarian cancers, 31 vulvar cancer...

Recently multiple cutaneous leiomyomas, uterine leiomyoimatosis and renal cancer have been described as a cancer syndrome with autosomal dominant pattern of inheritance.We report a 79-year-old man who presented with multiple hyperkertotic erythematous nodules on his right leg with histological diagnosis of pilar leiomyoma. In his past medical history several systemic co...