introduction: toluene is an organic solvent that it is one of the byproducts in the coke industry. exposure to toluene causes central nervous system dysfunction and others disorders. many workers are exposed to toluene due to leakage from tracks. therefore the aim of this study was to determine the levels of exposure through environmental and biological monitoring of toluene methods: air toluen...

A rapid, sensitive, and specific method for quantification of orotic acid from dried filter-paper urine samples is described. The method involves stable isotope dilution with 1,3-[15N2]orotic acid analysis by gas chromatography-mass spectrometry. The assay is sufficiently sensitive to be used with solvent extraction techniques commonly used for urinary organic acid analysis. Extraction efficien...

IT SEEMS DESIRABLE TO EMPHASIZE THE FOLLOWING CONCLUSIONS: 1. A careful balancing of the normal acids and bases of the urine makes it possible not merely to detect the presence of organic acids in the urine, but also to determine approximately the amount of such acids. The method recently described by Herter and Wakeman can be recommended as securing a greater degree of accuracy, for the amount...

BACKGROUND Increase in the incidence of hyperuricemia associated with gout as well as hypertension, renal diseases and cardiovascular diseases has been a public health concern. We examined the possibility of facilitated excretion of uric acid by change in urine pH by managing food materials. METHODS Within the framework of the Japanese government's health promotion program, we made recipes wh...

objective: finding a suitable laboratory test that can diagnose schizophrenia in its early stages could be very important. according to the hypothesis of lack of noradrenalin balance in the brain, it is illustrated that the disorder severity has a negative correlation with the amount of urine noradrenalin metabolite [3-methoxy-4-hydroxy phenyl glycol (mhpg) sulfate]. in this research, instead o...

Pancytopenia in childhood can be caused by a variety of underlying diseases including hematological and non-hematological entities. Phenylketonuria (PKU) is an inborn error of phenylalanine metabolism. No association between PKU and pancytopenia has ever been reported. We report the first case of PKU revealed by a pancytopenia at presentation. The patient was an infant girl born to healthy non-...

BACKGROUND The acid-ash hypothesis, the alkaline diet, and related products are marketed to the general public. Websites, lay literature, and direct mail marketing encourage people to measure their urine pH to assess their health status and their risk of osteoporosis.The objectives of this study were to determine whether 1) low urine pH, or 2) acid excretion in urine [sulfate + chloride + 1.8x ...

BACKGROUND Urinary organic acids are water-soluble intermediates and end products of the metabolism of amino acids, carbohydrates, lipids, and a number of other metabolic processes. In the hereditary diseases known as organic acidurias, an enzyme or co-factor defect in a metabolic pathway leads to the accumulation and increased excretion of one or more of these acidic metabolites. Gas chromatog...

The concept of an increased formation and excretion of acids in pneumonia seems to have first found experimental justification in the work of Palmer and Henderson (l), who found that the administrat,ion of 4 gm. of sodium bicarbonate did not appreciably change the reaction of the urine of a patient with pneumonia. In normal individuals this amount of bicarbonate produced a change in reaction of...

We describe a complete procedure for separation and mechanized analysis of organic acids in human urine. The acid fraction of urine is separated by anion-exchange chromatography on diethylaminoethyl-Sephadex. Individual acids are identified and measured by use of a gas-chromatography/mass spectrometer/computer system that can clearly distinguish contributions from at least 150 substances in a s...