In the present study, starting compound 4 was prepared by deamination of compound 2 in the presence of hypophosphorous acid and sodium nitrite. Treatment of compound 4 with ethyl bromoacetate produced ethyl[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl]acetate (5), which was converted to the hydrazide derivative (6) by treatment with hydrazine hydrate. The reaction of compound 6 ...

Background: Klebsiella pneumoniae is one of the most important bacteria that cause nosocomial infections. This opportunistic pathogen has a high potential for antibiotic resistance and can generate a thick layer of biofilm. Nowadays, antibiotic resistant strains are emerging and widely spreading worldwide. Thus, it is necessary to combat drug-resistant strains through the use of novel drugs (su...

this study was aimed to evaluate the antioxidative and urease inhibitory properties of the extracts from citrullus colocynthis l. the extracts of the root and pulp of fruit were prepared by soxhlet apparatus in methanol as solvent. the antioxidative activities, including dpph radical scavenging activity, reducing power and total antioxidant activity were studied in vitro. the results showed tha...

urease enzyme has a crucial role in the persistent habitation of helicobacter pylori (h. pylori) that induces gastrointestinal diseases, in particular gastritis, duodenal, peptic ulcer, and gastric cancer. plants have long been utilized as the biggest source of substances with medicinal properties from natural origin and therefore result in less toxicity and adverse side effects upon usage. 15 ...

UNLABELLED BACKGROUND Jack bean urease (EC 3.5.1.5) is a metalloenzyme, which catalyzes the hydrolysis of urea to produce ammonia and carbon dioxide. The heavy metal ions are common inhibitors to control the rate of the enzymatic urea hydrolysis, which take the Hg2+ as the representative. Hg2+ affects the enzyme activity causing loss of the biological function of the enzyme, which threatens ...

Studies to evaluate more than 100 compounds as inhibitors of urease activity in soils showed that dihydric phenols and quinones were the most effective organic compounds tested and that silver and mercury salts were the most effective inorganic compounds. When the most potent inhibitors were compared using 50 1'8 of inhibitor per g of soil, their effectiveness decreased in the order: catechol >...

Studies on enzyme inhibition remain a crucial area in drug discovery since these studies have led to the discoveries of new lead compounds useful in the treatment of several diseases. In this study, protocatechuic acid (PCA), an active compound from Hibiscus sabdariffa L. has been evaluated for its inhibitory properties against jack bean urease (JBU) as well as its possible toxic effect on huma...

This study assesses the effects of herbicide oxyfluorfen on activities enzymes and populations soil microorganisms by considering experiments samples maintained in both laboratory field conditions. Furthermore, molecular docking approach was used to evaluate interactions with found soil. There a dose dependent inhibitory effect against dehydrogenase, phosphatase, protease urease. The obtained f...

Background: The growing spread of drug resistance in Helicobacter pylori has caused concern. Urease is one the most important enzymes associated with H. activity. Oxadiazoles have a wide range inhibitory activities. aim this study was to investigate new oxadiazole compounds as urease inhibitors pylori. Methods: synthesized were reused ligands previous study, and initial structure optimized by M...