نتایج جستجو برای: upa

تعداد نتایج: 2081  

Journal: :Cancer research 2001
S E Dunn J V Torres J S Oh D M Cykert J C Barrett

Elevated levels of urokinase plasminogen activator-1 (uPA) and the insulin-like growth factor-I receptor (IGF-IR) are associated with breast cancer recurrence and decreased survival. It is possible that activation of IGF-IR and elevations in uPA are mechanistically linked. Our laboratory recently showed that insulin-like growth factor-I (IGF-I) induces uPA protein and mRNA in the breast cancer ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Massimo Alfano Nicolai Sidenius Barbara Panzeri Francesco Blasi Guido Poli

Elevated levels of soluble urokinase-type plasminogen activator (uPA) receptor, CD87/u-PAR, predict survival in individuals infected with HIV-1. Here, we report that pro-uPA (or uPA) inhibits HIV-1 expression in U937-derived chronically infected promonocytic U1 cells stimulated with phorbol 12-myristate 13-acetate (PMA) or tumor necrosis factor-alpha (TNF-alpha). However, pro-uPA did not inhibi...

Journal: :Arthritis Research & Therapy 2003
Tao Jin Andrej Tarkowski Peter Carmeliet Maria Bokarewa

Urokinase plasminogen activator (uPA) is an important regulator of fibrinolysis in synovial fluid. An increase of uPA activity and expression of its receptor have been reported in joints of patients with rheumatoid arthritis (RA). The aim of the present study was to assess the arthritogenic capacity of uPA and the mechanisms by which this effect is mediated. uPA was injected into the knee joint...

2015
Chise Tateno Yosuke Kawase Yoshimi Tobita Satoko Hamamura Hiroki Ohshita Hiroshi Yokomichi Harumi Sanada Masakazu Kakuni Akira Shiota Yuha Kojima Yuji Ishida Hiroshi Shitara Naoko A. Wada Hiromi Tateishi Masayuki Sudoh Shin-ichiro Nagatsuka Kou-ichi Jishage Michinori Kohara Rafael Aldabe

We have used homozygous albumin enhancer/promoter-driven urokinase-type plasminogen activator/severe combined immunodeficient (uPA/SCID) mice as hosts for chimeric mice with humanized livers. However, uPA/SCID mice show four disadvantages: the human hepatocytes (h-heps) replacement index in mouse liver is decreased due to deletion of uPA transgene by homologous recombination, kidney disorders a...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2012
Jasmin Khateeb Yulia Kiyan Michael Aviram Sergey Tkachuk Inna Dumler Bianca Fuhrman

OBJECTIVE The atherosclerotic lesion is characterized by lipid peroxide accumulation. Paraoxonase 1 (PON1) reduces atherosclerotic lesion oxidative stress, whereas urokinase-type plasminogen activator (uPA) increases oxidative stress in atherosclerotic lesions and contributes to the progression and complications of atherosclerosis. We hypothesized that uPA may promote oxidative stress in the ar...

Journal: :The Journal of biological chemistry 1993
S S Husain

Interactions of components of the fibrinolytic system with fibrin play a key role in localization and regulation of plasminogen activation at the clot surface. Although interaction of tissue plasminogen activator (tPA) with fibrin is well established, the prevailing view is that urokinase-type plasminogen activator (uPA) does not bind to fibrin. In this report, I show that although there is lit...

Journal: :Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2003
Wei Xia Charles de Bock George A C Murrell Yao Wang

The urokinase-type plasminogen activator (uPA) system has been implicated in cell migration, angiogenesis, extracellular matrix synthesis and tissue remodelling. However, little is known about the role of the system in tendon healing. We used a rat Achilles tendon model to study mRNA and protein expression of uPA and its receptor (uPAR) during tendon healing using immunohistochemical, Northern ...

2014
Ji-Hye Lee Mee-Hye Oh Jae-Seok Park Gyoung-Jae Na Hye-Wook Gil Jong-Oh Yang Eun-Young Lee Sae-Yong Hong

BACKGROUND/AIMS The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA) glomerulonephritis (GN). METHODS Renal biopsy specimens from 52 IgA GN patients were deparaffinized and subjected to immunohistochemical staining for uPA, PAI-1, and uP...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2008
Bianca Fuhrman Jasmin Khateeb Maayan Shiner Orna Nitzan Rachel Karry Nina Volkova Michael Aviram

OBJECTIVE Macrophage foam cells are characterized by increased oxidative stress. Macrophage urokinase plasminogen activator (uPA) was shown to contribute to atherosclerosis progression. We hypothesized that uPA atherogenicity is related to its ability to increase macrophage oxidative stress. Increased macrophage oxidative stress in turn was shown to enhance PON2 expression. In the present study...

Journal: :Circulation research 2004
Hideaki Moriwaki April Stempien-Otero Michal Kremen Aaron E Cozen David A Dichek

Several studies implicate elevated matrix metalloproteinase activity as a cause of cardiac fibrosis. However, it is unknown whether other proteases can also initiate cardiac fibrosis. Because absence of urokinase plasminogen activator (uPA) prevents development of cardiac fibrosis after experimental myocardial infarction in mice, we hypothesized that elevated activity of uPA or deficiency of th...

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