In this article, optimization-based frameworks are introduced for elucidating the input-output structure of signaling networks and for pinpointing targeted disruptions leading to the silencing of undesirable outputs in therapeutic interventions. The frameworks are demonstrated on a large-scale reconstruction of a signaling network composed of nine signaling pathways implicated in prostate cance...

The purpose of this contribution1 is to set up a language to evaluate the results of concerted action among interdependent agents against predetermined properties that we can recognise as desirable from a deontic point of view. Unlike the standard view of logics to reason about coalitionally rational action, the capacity of a set of agents to take a rational decision will be restricted to what ...

Frequently undesirable outputs are produced together with desirable. This joint production of bad and good outputs in connection with environmental decision models is the subject of this paper. Recently Haynes, Ratick, Bowen and Cummings-Saxton (1993) addressed the same subject matter. They observed that: "... input resources, including the chemicals of concern, produce as joint products the sa...

The linear programming formulations of model predictive control are known to exhibit degenerate solution behavior. In this work, a multi-parametric linear programming technique is utilized to analyze the control laws that are generated from various linear programming based MPC routines. These various routines explore a number of factors, including objective function selection and constraint han...

In chapter 12 it was pointed out that when the same input vector X is applied to a multiplicity of adaptive Instar maps, some mechanism must exist for determining which Instar or Instars, if any, will respond to the input by adapting their weights. The problem of coming up with such a mechanism is what we will here call "the partitioning problem." The precise mechanism by which the partitioning...

In process multi-input multi-output (MIMO) systems are observed that are dominated by interactions between input and outputs. Process decouplers are synthesized to reduce these interactions before controller design. In this work analytical expressions for closed-loop interactive transfer functions are found and interaction reducers (IR) are designed (as process decouplers) for closed-loop contr...

This study estimates the environmental efficiency of international listed firms in 10 worldwide sectors from 2007 to 2013 by applying an order-m method, a non-parametric approach based on free disposal hull with subsampling bootstrapping. Using a conventional output of gross profit and two conventional inputs of labor and capital, this study examines the order-m environmental efficiency account...