objective(s) we investigated the effects of low-dose morphine on nitric oxide (no) and angiogenesis in two-kidney one clip hypertensive (2k1c) rats. materials and methods male rats were divided into two groups: sham-clip operated and 2k1c. each group subdivided into saline and morphine (3 mg/kg i.p. 8 weeks) groups. blood pressure, heart rate, plasma renin activity (pra), no concentration and m...

Binding a critical pentapeptide region on the scaffolding protein filamin A regulates signaling of mu opioid receptors (MORs) so that their activation should not result in the opioid tolerance, dependence and addiction associated with current opioid painkillers. Additionally, we show that compounds that bind this site on filamin A reduce release of inflammatory cytokines. PTI-609 is a new chemi...

Introduction: Nucleus accumbens (NAc) plays a critical role in neuronal reward circuits that are responsible for motivated and goal-directed behaviors. Some data suggest that morphine induces apoptosis in neurons, while other evidences show that morphine could have beneficial effects against neuronal cell death. This study was designed to evaluate the effect of morphine on apoptosis in the N...

The aim of this study was to evaluate the effect of curcumin on morphine tolerance and the corresponding cytokine/chemokine changes. Male ICR mice were made tolerant to morphine by daily subcutaneous injection for 7 days. Intraperitoneal injections of vehicle, low-dose or high-dose curcumin were administered 15 min after morphine injection, either acutely or chronically for 7 days to test the e...

conclusions analysis of codeine to morphine metabolism rate is needed when we are using morphine/codeine ratio to rule out abuse of narcotics. wada should consider analysis for the cyp2d6 alleles (main metabolizer of codeine) in case of including morphine/codeine ratio in future prohibited list. the possibility of ultra-rapid cyp2d6 cannot be ruled out in certain results of morphine/codeine nea...

objective: acute inflammatory demyelinating peripheral neuropathy (guillain-barre-syndrome) is by far the most common cause of immune-medicated peripheral nervous system disease in children; with the near disappearance of poliomyelitis, gbs is responsible for the great majority of cases of acute flaccid paralysis. so far, in several controlled studies, corticosteroids, plasmapheresis and ivig h...

Opioid rotation has been proposed for management of cancer pain. No studies directly investigating dose equivalence between morphine injection (continuous IV administration) and the transdermal fentanyl patch have been reported. Therefore, we examined dose conversion ratios in patients undergoing opioid rotation from morphine injection to fentanyl patches. The subjects consisted of 45 patients ...