Peptic ulcer is a common disorder of the stomach and duodenum. Herbs and medicinal plants are considered to be a potential source to combat various diseases including gastric ulcer. The present study was conducted to evaluate the gastro protective effects of Echinacea extract, Green tea extract and Boswellia extract on a pyloric ligation-induced gastric ulcer. Six groups of rats were intraperit...

Background: Foot ulceration (DFU) is a serious complication of diabetes and new techniques that can predict wound healing may prove very helpful. We tested the ability of Medical Hyperspectral Technology (HT), a novel diagnostic scanning technique which can quantify tissue oxyand deoxyhemoglobin, to predict DFU healing. Methods: Ten T1DM patients with 21 foot ulcer sites, 13 T1DM without ulcers...

The mechanism of acute gastric ulceration in rats with obstructive jaundice was investigated in terms of the changes in the gastric mucosal blood flow, and the effect of vagotomy on ulceration was examined. 188 Sprague-Dawley rats weighing about 250 g were prepared and divided into 4 groups as follows; control group (sham operation), jaundiced group (ligation of the bile duct), vagotomized grou...

Ulcer formation after pylorus ligation was assessed in control, testosterone treated and castrated male rats after cimetidine treatment. The stomach was studied for incidence of ulcers and its contents analysed for pH, volume, total acidity, free acidity, pepsin and mucin activity. Testosterone and cimetidine when used alone protected from ulceration while when used in combination the degree of...

spasmolytic, antioxidant, anti-inflammatory and immuno-modulatory properties of ginger (rhizome of zingiber officinale roscoe) suggest that it may has beneficial effects on inflammatory bowel diseases. in the present study, the effect of this herbal extract on a model of acute colitis was evaluated. ginger hydroalcoholic extract with doses of 150, 350, 700 mg/kg, prednisolone (2 mg/kg), or vehi...

The present study was designed to study the effect of SR 58611A, a selective beta 3-adrenoceptor agonist against gastric ulcers: pylorus ligation, water immersion plus restraint stress (WIRS), ethanol, aspirin-induced and on cysteamine-induced duodenal ulcers, in rats. SR 58611A (10 mg/kg, p.o.) was found to be effective in attenuating gastric ulceration and the results were comparable with tho...

Ulcer is a common problem associated with NSAID’s use. The use of plants to treat and cure diseases is common practice since ancient times because of people blind faith on safety of plant’s use. The present study aimed to evaluate anti-ulcer activity of Dalbergia sissoo in alcohol and aspirin induced ulcerative rat models. Animals were divided into four groups. Group I was disease control, grou...

AIMS To determine clinical outcomes and explore prognostic factors related to ulcer healing in people with a clinically infected diabetic foot ulcer. METHODS This multicentre, prospective, observational study reviewed participants' data at 12 months after culture of a diabetic foot ulcer requiring antibiotic therapy. From participants' notes, we obtained information on the incidence of wound ...

Persistent exacerbation of a peptic ulcer may lead to a complicated peptic ulcer (perforation or/and bleeding). The management of complicated peptic ulcers has shifted from acid-reducing vagotomy, drainage, and gastrectomy to simple local suture or non-operative (endoscopic/angiographic) hemostasis. We were interested in the long-term effects of this trend change. In this study, complicated pep...

Vagus nerve may play a role in serum glucose modulation. The complicated peptic ulcer patients (with perforation or/and bleeding) who received surgical procedures with or without vagotomy provided 2 patient populations for studying the impact of vagus nerve integrity. We assessed the risk of developing type 2 diabetes in peptic ulcer patients without and with complications by surgical treatment...