Antibiotics, commonly amoxycillin, tetracycline, metronidazole and clarithromycin, are presently used in combination with anti-ulcer agents such as omeprazole, colloidal bismuth subcitrate, and sucralfate to treat Helicobacter pylori infection in patients with peptic ulcer, and compelling evidence has accumulated that eradication of the organism prevents duodenal ulcer relapse. The latest combi...

Gastric ulcer is a multifaceted, pluricausal illness. Knowledge of the pathophysiology of gastric ulcer disease remains incomplete. Current pharmacological management of gastric ulceration is directed primarily at the reduction or neutralization of gastric acid secretion despite evidence that patients with this disease often exhibit normal gastric secretory activity. Attempts have been made to ...

Medicinal plants have been widely studied to identify plant-based anti-gastric ulcer medicines. The mechanism of gastroprotective action is important discover the potential lead compounds for drug development. All relevant articles between 2011 and 2021 focusing on Malaysian were collected analyzed understand underlying pathways. Keywords include peptic ulcer, gastric NSAIDs (Non-Steroidal Anti...

Peptic ulcer disease is a multifactorial and complex disease involving gastric and duodenal ulcers. Despite medical advances, the management of peptic ulcer and its complications remains a challenge, with high morbidity and death rates for the disease. An accumulating body of evidence suggests that, among a broad reach of natural molecules, dietary polyphenols with multiple biological mechanism...

Phytochemicals are known for their therapeutic effects through diverse mechanisms such as modulators, substrate ligands, receptor enzyme cofactors, enzymes precursors, toxins scavengers, microbial growth inhibitors, agents, and enhancers in the treatment of various diseases ailments. Folklorically, indigenous people Nigeria have used Desmodium velutinum (Fabaceae) disease conditions headache, f...

Recently interest in investigations of adrenergic agents (stimulants and inhibitors) on gastric secretion, motility, and ulceration in experimental animals has increased (1-7). Pradhan and Wingate (6) have demonstrated that phentolamine and tolazoline enhanced the spontaneous gastric secretion in dogs while phenoxybenzamine and dichloroisopro terenol showed inhibitory effects on spontaneous as ...

normal! NIDDMrats by various physical (2 hrs cold restraint stress and 4 hours pylorus ligation) and chemical agents (ethanol, 1 mJ/200g, oral, 1 hr before; aspirin, 200 mglkg, oral) and duodenal ulcers were induced by cysteamine (40 mg!200g). Ulcer healing activitywas studied in gastric ulcers induced by acetic acid (50%) and HCI (0.6 M). The result indicated that in both, normal and NlDDM rat...

Gastric ulcers were induced in normal/NIDDM rats by various physical (2 hr cold restraint stress and 4 hr pylorus ligation) and chemical agents (ethanol, 1 ml/200 g, oral, 1 hr before; aspirin, 200 mg/kg, oral, 4 hr) and duodenal ulcers were induced by cysteamine (40 mg/200 g). Ulcer healing activity was studied in gastric ulcers induced by acetic acid (50%) and HCI (0.6 M). The result indicate...

BACKGROUND The use of acid-decreasing agents in the management of peptic ulcer haemorrhage continues to be controversial. Most clinical trials examining the efficacy of these drugs contain small numbers of patients, making it difficult to draw conclusions about their efficacy. METHODS We report a meta-analysis that examined the effect of these drugs in the management of peptic ulcer haemorrha...