In order to elucidate the mechanism underlying enhancement by ethanol of N-nitrosodiethylamine (DEN)- and N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in rats, hepatic levels of cytochrome P-450 (CYP) enzymes, mutagenic activation of several N-nitrosamines and three kinds of UDP-glucuronyltransferase (UDPGT) activities were assayed in F344 rats. Immunoblot analyses of micr...

Organic iodides have been shown to induce thyroid hypertrophy and increase alterations in colloid in rats, although the mechanism involved in this toxicity is unclear. To evaluate the effect that free iodide has on thyroid toxicity, we exposed rats for 2 weeks by daily gavage to sodium iodide (NaI). To compare the effects of compounds with alternative mechanisms (increased thyroid hormone metab...

Human exposure to phthalic acid diesters occurs through a variety of pathways as a result of their widespread use in plastics. Repeated doses of di-n-butylphthalate (DBP) from gestation day (GD) 12 to 19 disrupt testosterone synthesis and male sexual development in the fetal rat. To gain a better understanding of the relationship of the target tissue (testes) dose to observed developmental effe...

The improvement of cold adaptation has contributed to the increased growing area rice. Standing variation and de novo mutation are distinct natural sources beneficial alleles in plant adaptation. However, genetic mechanisms evolutionary patterns underlying these a single population during crop domestication remain elusive. Here we cloned CTB2 gene, encoding UDP-glucose sterol glucosyltransferas...

Respiratory tract biotransformation of many xenobiotics found in inhaled environmental pollutants is generally considered es sential for the mutagenic, carcinogenic, and/or toxic response of lung tissue to these xenobiotics. Typical environmental pollutants contain known carcinogens adsorbed onto particles which can deposit in the nasal pharyngeal region of the respiratory tract. The purpose of...

A rare case of Gilbert syndrome during pregnancy was reported at Narayana Medical College and Hospital's obstetrics department. Due to the fact that it an extremely with a typical presentation, properly studied analysed provide thorough report. 36-week-pregnant primigravida who had been having nausea, vomiting, stomach pain, myalgia, yellowish discoloration both skin sclera for past five days p...

Repeated inhalation exposure to octamethylcyclotetrasiloxane (D4) produces a reversible and dose-related hepatomegaly and proliferation of hepatic endoplasmic reticulum in rats. However, the effects of D4 on the expression of cytochrome P450 enzymes have not been evaluated. In the present study, the time course for changes in hepatic microsomal cytochrome P450 enzyme expression following repeat...

Cytochromes P450 (CYP, phase I) and conjugating (phase II) enzymes can be induced by and influence the toxicokinetics (metabolism) and toxicity of xenobiotic contaminants in exposed organisms. Beluga whale (Delphinapterus leucas) from the endangered St. Lawrence (SL) River Estuary population exhibit deleterious health effects and various severe pathologies that have been associated with contami...

BACKGROUND & OBJECTIVES Our previous study showed that cow ghee relative to soybean oil had a protective effect against carcinogen induced mammary cancer in rats. The objective of this study was to elucidate its biochemical mechanism. METHODS Two groups of 21 day old rats (20 each) were fed for 44 wk diet containing cow ghee or soybean oil (10%). Five animals from each group were sacrificed a...