iii Populärvetenskaplig sammanfattning v Original Papers vii Introduction 1 Historical overview 1 Criteria for diagnosis of diabetes 4 Background to this thesis 5 Type 1-diabetes in childhood 5 Etiology 6 Genetic predisposition 7 Environmental risk factors 7 Type-2 diabetes in childhood 9 Diabetes related health complications 10 Renal disease in T1D patients 11 Mortality in T1D patients 13 Aim ...

Increased renal endothelin-1 (ET-1) production and an ETA receptor-dependent increase in glomerular albumin permeability (Palb) accompany type 1 diabetes mellitus (T1D). We hypothesized that T1D-induced oxidative stress contributes to renal ET-1 production and glomerular Palb Male rats with streptozotocin-induced T1D were provided free access to drinking water without additives (T1D rats) or co...

Interleukin-1 antagonism is a proposed biomarker and potential therapy for the delay and/or treatment of type 1 diabetes (T1D). We evaluated role circulating interleukin-1 receptor antagonist (IL-1ra) in prospectively monitored cohort T1D patients. In order to determine mechanistic association between IL-1ra T1D, we performed co-localization analyses serum protein quantitative trait loci genome...

Diabetes mellitus encompasses two distinct disease processes: autoimmune Type 1 (T1D) and nonimmune Type 2 (T2D) diabetes. Despite the disparate aetiologies, the disease phenotype of hyperglycemia and the associated complications are similar. In this paper, we discuss the role of the CD39-adenosinergic axis in the pathogenesis of both T1D and T2D, with particular emphasis on the role of CD39 an...

Objective: Meal management in Type 1 Diabetes (T1D) has barriers such as miscalculation of doses, insufficient carbohydrate counting and numeracy skills. “My Friend Carbohydrate Bolus Calculator” mobile app was developed a hybrid version nutrition apps insulin titration to calculate meal’s carbs the matching bolus dose. This study investigates facilitator role on lives people with T1D. Material...

Background According to the IDF the number of cases worldwide reached 387 million in 2014, while Brazil occupies the 4th place in the overall ranking with over 13 million cases. These data refer to both Type 2 Diabetes (T2D) and T1D. Although T1D affects the minority of patients, it is responsible for many of the serious complications. T1D, usually diagnosed in youth, requires continuous treatm...

While significant research has clearly identified sedentary behavior as a risk factor for type 2 diabetes and its subsequent complications, the concept that inactivity could be linked to the complications associated with type 1 diabetes (T1D) remains underappreciated. This paper summarizes the known effects of exercise on T1D at the tissue level and focuses on the pancreas, bone, the cardiovasc...

Cardiovascular disease (CVD) constitutes the major cause of mortality and morbidity in both type 1 (T1D) and type 2 (T2D) diabetes patients. Although the microvascular complications of T1D are well studied, macrovascular CVD, its treatment, and link to diabetes have been investigated primarily in T2D patients. On April 27 and 28, 2003, the National Heart, Lung, and Blood Institute (NHLBI) and t...

Background: Type 1 diabetes (T1D) is a T cell mediated autoimmune disease targeting the insulin-producing β cells within pancreatic islets. Autoimmune diseases may develop as a consequence of altered balance between regulatory (Tregs) and autoreactive T cells. Objectives: To evaluate Treg cells frequency and suppressive function in the peripheral blood of newly diagnosed T1D patients in compari...