BACKGROUND Chronic lung infection with Pseudomonas aeruginosa occurs in approximately 50% of patients with cystic fibrosis (CF). This infection further compromises lung function, and significantly contributes to the increased healthcare costs. OBJECTIVES Inhaled tobramycin, used to manage P. aeruginosa infection in CF patients, is available as powder (tobramycin inhalation powder, TIP) and so...

Abstract. The subglacial bed topography is critical for modelling the evolution of Thwaites Glacier in Amundsen Sea Embayment (ASE), where rapid ice loss threatens stability West Antarctic Ice Sheet. However, mapping subject to uncertainties up hundreds metres, primarily due large gaps tens kilometres airborne ice-penetrating radar flight lines. Deterministic interpolation approaches do not ref...

Transition Initiation Sites (TIS) prediction is a challenging problem in computational biology. In the literature TIS is predicted using various machine learning techniques such as Neural Network (NN), Support Vector Machine, etc. We have applied Principal Component Analysis (PCA) to remove highly correlated features which improves the performance in terms of time and accuracy. In this paper we...

Numerical graph theoretic invariants or topological indices (TIs) and principal components (PCs) derived from TIs have been used in discriminating a set of isospectral graphs. Results show that lower order connectivity and information theoretic TIs suffer from a high degree of redundancy, whereas higher order indices can characterize the graphs reasonably well. On the other hand, PCs derived fr...

A probabilistic strategy, early termination, enables different interpolation algorithms to adapt to the degree or the number of terms in the target polynomial when neither is supplied in the input. In addition to dense algorithms, we implement this strategy in sparse interpolation algorithms. Based on early termination, racing algorithms execute simultaneously a dense and a sparse algorithm. Th...

In commercial transactions, trust in sellers (TIS) is the degree of trust that buyers bestow upon sellers. The existence and level of TIS is obviously a factor determining whether buyers will buy. TIS is particularly important in consumer-to-consumer e-commerce transactions, such as online auctions, which are characterized by anonymity and asymmetric product quality information. Given the impor...

Abstract. For the construction of digital terrain models based on surface interpolation, it is defined a bivariate function that interpolates a finite set of sample points, , such that, . In this work, it is presented a strategy for the generation of interpolation surfaces through the use of basis functions. This methodology is based on a work by Chaturvedi and Piegl, where improvements related...