Background There have been conflicting reports regarding the possibility of an association between Lynch syndrome and prostate cancer. Some reports indicate that individuals with mismatch repair gene mutations may be at an increased risk of prostate cancer, while others show little to no evidence of an association. We are reporting a family with multiple cancers including colorectal, endometria...

Lynch syndrome is the most common inherited colorectal cancer susceptibility syndrome and accounts for approximately 3 % of all colorectal cancers. Clinical assessment and a detailed family history are crucial in identifying patients who need further evaluation via genetic counseling and testing. Discovery of the underlying causative germline mutations in DNA mismatch repair genes has allowed m...

the most important factor in donor-recipient matching for hematopoietic stem cell transplantation is their hla typing. for many patients, we can not find a full-matched donor. in high risk patients, one locus  mismatched related donors are suitable alternatives. (1, 2) since the matching of patients and their siblings usually is based on low resolution hla typing, the matching of one locus mism...

Correspondence to: Young-Bok Jung, MD Emeritus Professor, Chung Ang University, Seoul Joint Center, Hyundae General Hospital, 663 Janhyn-ri, Jinjeop-eup, Namyangju 472-865, Korea Tel: +82-31-574-9119, Fax: +82-31-874-3779 E-mail: [email protected] There have been many recent improvements in cruciate ligament surgery of the knee. The anterior cruciate ligament (ACL) reconstruction has been ch...

background: meiotic genes are very important candidates for genes contributing to female and male infertility. mammalian mutl homologues have dual roles in dna mismatch repair (mmr) after replication errors and meiotic reciprocal recombination. the mutl homologs, mlh1 and mlh3 , are crucial for meiotic reciprocal recombination and human fertility. in this study the functional polymorphisms of m...

nowadays deep excavations are needed for construction of foundation of high rise buildings, providing space for parking and etc. in some cases deep excavations may be constructed in the vicinity of the subway tunnels and causes unpredicted extra displacements and internal forces in tunnel lining of tunnels which were not designed for them and consequently affect serviceability of tunnel. theref...

the construction of underground tunnel plays a more and more important role in the development of big cities. one of the most important problems caused by the construction of the tunnel is that underground excavation will cause large settlement of the ground and buildings. previous studied showed the difference between numerical and experimental results. in this study the case study of niyayesh...

We report on the electrical characterization of one-sided p(+)-si/n-InAs nanowire heterojunction tunnel diodes to provide insight into the tunnel process occurring in this highly lattice mismatched material system. The lattice mismatch gives rise to dislocations at the interface as confirmed by electron microscopy. Despite this, a negative differential resistance with peak-to-valley current rat...

Modern technology has been used to build tunnels in recent years by means of drilling machines (TBM) that were used for civil engineering work in large cities to reduce the harmful effects of spending on the surface of the earth significantly. To build the tunnel, numerical modeling was used on the basis of the finite element method to predict stress behavior during the tunnel construction proc...