Submit Manuscript | http://medcraveonline.com Abbreviations: AhR: Aryl Hydrocarbon Receptor; Arnt: Nuclear Translocator; CLP: Cecal Ligation and Puncture; CVB3: Coxsackievirus B3; CRP: C-Reactive Protein; CYP-450: Cytochrome P-450; ECOD: Ethoxycoumarin O-Deethylase; GH: Growth Hormone; IMND: Imipramine N-Demethylase; iNOS: inducible Nitric Oxide Synthetase; icv: intracerebroventricularly; IFN-γ...

Submit Manuscript | http://medcraveonline.com Abbreviations: AhR: Aryl Hydrocarbon Receptor; Arnt: Nuclear Translocator; CLP: Cecal Ligation and Puncture; CVB3: Coxsackievirus B3; CRP: C-Reactive Protein; CYP-450: Cytochrome P-450; ECOD: Ethoxycoumarin O-Deethylase; GH: Growth Hormone; IMND: Imipramine N-Demethylase; iNOS: inducible Nitric Oxide Synthetase; icv: intracerebroventricularly; IFN-γ...

Taiwan wild grape (Vitis thunbergii var. taiwaniana; VTT) is an important traditional herbal medicine used to treat muscle injuries and acute and chronic pain of the ligaments. Information on its bioactivity and the underlying mechanisms, which have not been elucidated thus far, is needed to demonstrate its value for pharmacological and clinical use. This study presents evidence to clarify the ...

Objective(s): An increase in nitric oxide (NO) production has been reported in cirrhotic cardiomyopathy and, portal hypertension. Since minocycline has been shown to inhibit NO overproduction, we aimed to examine its role in a rat model of CCl4-induced cirrhotic cardiovascular complications. Materials and Methods: Portal pressure and inotropic responsiveness of isolated papillary muscles to is...

Objective—Red wine (RW) consumption has been associated with a reduction of cardiovascular events, but limited data are available on potential mediating mechanisms. This study tested the hypothesis that intake of RW may promote the circulating endothelial progenitor cell (EPC) level and function through enhancement of nitric oxide bioavailability. Methods and Results—Eighty healthy, young subje...

OBJECTIVE Red wine (RW) consumption has been associated with a reduction of cardiovascular events, but limited data are available on potential mediating mechanisms. This study tested the hypothesis that intake of RW may promote the circulating endothelial progenitor cell (EPC) level and function through enhancement of nitric oxide bioavailability. METHODS AND RESULTS Eighty healthy, young sub...

Cytokines such as gamma interferon and tumor necrosis factor alpha (TNF-alpha) inhibit the intracellular replication of Chlamydia pneumoniae or Chlamydia trachomatis. In this study, we found that another cytokine, lymphotoxin (TNF-beta), restricts the growth of C. pneumoniae in HEp-2 cells. When lymphotoxin (10 U/ml) was added during incubation from 8 to 16 h postinoculation, inclusion body for...

Endothelial cell-based angiogenesis requires activation of survival signals that generate resistance to external apoptotic stimuli, such as tumor necrosis factor-alpha (TNF-alpha), during pathobiologic settings. Mechanisms by which this is achieved are not fully defined. Here, we use a model in which the multifunctional cytokine nitric oxide counterbalances TNF-alpha-induced apoptosis, to defin...

The purpose of these studies was to determine whether nitric oxide produced by cytokine-activated murine lung vascular endothelial cells plays a role in their lytic destruction of M-5076 reticulum cell sarcoma. Vascular endothelial cells harvested from perfused lungs of mice were adapted to grow in culture. Cloned lines ascertained to be of endothelial origin were incubated in vitro with interf...