Tumor-associated macrophages (TAMs) provide a significant contribution to tumor growth and metastasis. We demonstrated the existence of two main TAM subsets, differing in activation state and localization. Of these, M2-like TAMs reside in hypoxic regions of the tumor mass and can be used as targets for hypoxia tracers. This said, hypoxia does not regulate the differentiation of TAMs but finely ...

Taniguchi et al . (Research Articles, 17 July 2020, p. 269) claim that the cytokine interleukin-33 induces accumulation of tumor-associated macrophages expressing immunoglobulin E receptor FcεRI. Although these findings hold great therapeutic promise, we provide evidence anti-FcεRI antibody used in this study is not specific for FcεRI on macrophages, which raises concerns about validity some co...

Multiple Myeloma (MM), a bone marrow plasma cell hematopoietic cancer, remains critical but incurable hematological malignancy, prone to deadly relapses even after existing treatment. In this review, I describe the origins of pro-tumor myeloma-associated macrophages. specifically outline how classically activated anti-tumor macrophages that home cancerous tumor microenvironment is polarized int...