INTRODUCTION Connexin 43 (Cx43) mediates the effect of thyroid hormone on Sertoli cell maturation in vitro. We investigated the influence of triiodothyronine (T3) administration on Cx43 expression in relation to the progress in seminiferous tubule maturation. MATERIAL AND METHODS Male rats were daily injected with 100 µg T3/kg body weight from birth until postnatal day (pnd) 5 (transient trea...

BACKGROUND periodic paralysis related to hypokalemia is seldom reported in thyrotoxicosis, and it usually occurs in Asian males. PATIENTS AND METHODS Two Romanian (Caucasian) young patients presented with hypokalemic paralysis. TSH, FT4, TT3 was measured by immunochemiluminescence. Case report 1. Patient O.R, aged 19, presented marked asthenia and lower limbs paralysis, following high carbohy...

OBJECTIVE To establish trimester specific reference intervals for thyroid hormones during pregnancy in Malaysian women. STUDY DESIGN Cross-sectional observational study performed in the Obstetric Clinic, University Malaya Medical Centre. A single blood sample from 626 women at various trimesters of pregnancy was analyzed for thyroid function. TSH, FT4, TT4, FT3 and TT3 values at each trimeste...

lntraand interindividual components of biological variation have been determined for total thyroxin (TT4), free thyroxin (FT4), total triiodothyronine (TT3), free tniodothyronine (FT3), and thyrotropin (TSH). Calculated analytical goals (CV, %) for the precision required for optimal patient care are: TT4 2.5, FT4 4.7, TT3 5.2, FT3 3.9, and TSH 8.1. The marked degree of individuality demonstrate...

Landmark analyses are used to investigate the importance for survival of achieving complete response (CR), an important initial goal of myeloma therapy. With median times to CR in Total Therapy (TT) trials of approximately 1 year, this approach excludes a sizeable fraction of patients dying before such a landmark. To permit inclusion of all trial participants, we investigated the prognostic imp...


 Purpose: The current study investigates the effects of bee propolis as a dietary supplement on thyroid function in healthy individuals.
 Methods: Sixty-nine apparently subjects both genders aged between 25 and 45 years had body mass index range 18.5-25 kg m-2 were enrolled study. participants divided into two groups, 34 volunteers treated with 1 gram daily other 35 placebo pills for...

BACKGROUND Heavy metals, such as lead (Pb), mercury (Hg), and cadmium (Cd), are known toxicants, but their associations with the thyroid axis have not been well quantified at U.S. background levels. OBJECTIVES We investigated the relationships between thyroid hormones (total and free thyroxine [TT4 and FT4], total and free triiodothyronine [TT3 and FT3], thyroid-stimulating hormone [TSH], and...

Woodchucks ( n = 12-14/group) with circannual cycles entrained to northern versus southern hemisphere photoperiods were assessed monthly for 16 mo. Changes in serum total triiodothyronine (TT3), free thyroxine (T4), total thyroxine (TT4), and prolactin were determined in a subset of five animals per group. Metabolic hormone results were examined in relation to changes in body weight, food intak...

BACKGROUND Triiodothyronine (T3) has many effects on the heart, and marked changes in cardiac function and structure occur in patients with (subclinical) thyroid disease. We investigated whether between-subject variation in thyroid hormone levels within the euthyroid range is also associated with heart rate and echocardiographic heart function and structure. METHODS Subjects were selected fro...

BACKGROUND It is well known that certain non-thyroidal critical illness may lead to euthyroid sick syndrome(ESS). There are little reports about the change of thyroid hormone in the children's central nervous system (CNS) infections. RESULTS The results of serum TT3, TT4 and TSH in these children were compared with those in 20 cases of healthy adults and 20 cases of adults with primary hypoth...