In this work, we introduce DIRECTGO , a new MATLAB toolbox for derivative-free global optimization. collects various deterministic DIRECT -type algorithms box-constrained, generally constrained, and problems with hidden constraints. Each sequential algorithm is implemented in two ways: using static dynamic data structures more efficient information storage organization. Furthermore, parallel sc...

Despite the worldwide eradication of smallpox in 1979, the potential bioterrorism threat from variola virus and the ongoing use of vaccinia virus (VACV) as a vector for vaccine development argue for continued research on VACV. In China, the VACV Tiantan strain (TT) was used in the smallpox eradication campaign. Its progeny strain is currently being used to develop a human immunodeficiency virus...

TT virus (TTV) is not only an infectious agent of worldwide distribution but has also been demonstrated in various non-human primates in addition to humans. In the present study, we subjected the sera of 67 gibbons to PCR and nucleotide sequencing, with subsequent phylogenetic analysis to determine the nature of the relationship between TTV found in humans and non-human primates. We discovered ...

s, Posters and Oral presentation on national and international conferences 1. Blazsek A., Farkas L., Nyitray L.: Miozin Rúd Fragmentumok Vizsgálata, Avagy Egy Molekuláris Cipzárban Rejlő Lehetőségek. Xxvi. Biológus Otdk 2. Blazsek A., Ifj. Gergely P. , Zs. Weiszhár, K. Beke, G. Poór: Tt Vírus Kimutatása Autoimmun Reumatológiai Megbetegedésekben. Mit Xxxiv. Vándorgyűlés 3. Zs. Weiszhár, Ifj. Ger...

We report the isolation of 24 novel genotypes of TT viruses from a surgically removed spleen of a patient with Hodgkin's disease. The sequence analysis of our 24 isolates revealed the remarkable heterogeneity of TT virus isolates not only from the same patient but also from the same biopsy material. These isolates belong to four phylogenetic groups of TT viruses. Nucleotide sequence analyses re...

Interleukin 28B (IL28B) rs12979860 polymorphisms were examined in 41 individuals with human T-lymphotrophic virus type 1 (HTLV-1). The alleles CT/TT were more frequent in 12 individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis than in 29 asymptomatic carriers (80% vs 20%; P = .03), and median HTLV-1 proviral load was greater in CT/TT than CC carriers (P = .01). Thus, IL28B...