نتایج جستجو برای: trx

تعداد نتایج: 1013  

2015
Kento Nishida Hiroshi Watanabe Shigeru Ogaki Azusa Kodama Ryota Tanaka Tadashi Imafuku Yu Ishima Victor Tuan Giam Chuang Masao Toyoda Masumi Kondoh Qiong Wu Masafumi Fukagawa Masaki Otagiri Toru Maruyama

Rhabdomyolysis-associated acute kidney injury (AKI) is a serious life-threatening condition. As such, more effective strategies are needed for its prevention. Thioredoxin-1 (Trx), a redox-active and macrophage migration inhibitory factor (MIF) modulating protein, has a short retention time in the blood. We examined the renoprotective effect of long acting Trx that was genetically fused with hum...

2009
Goedele Roos Nicolas Foloppe Koen Van Laer Lode Wyns Lennart Nilsson Paul Geerlings Joris Messens

The dissociation mechanism of the thioredoxin (Trx) mixed disulfide complexes is unknown and has been debated for more than twenty years. Specifically, opposing arguments for the activation of the nucleophilic cysteine as a thiolate during the dissociation of the complex have been put forward. As a key model, the complex between Trx and its endogenous substrate, arsenate reductase (ArsC), was u...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
Eric Gelhaye Nicolas Rouhier Joelle Gérard Yves Jolivet José Gualberto Nicolas Navrot Per-Ingvard Ohlsson Gunnar Wingsle Masakazu Hirasawa David B Knaff Hongmei Wang Pierre Dizengremel Yves Meyer Jean-Pierre Jacquot

The plant mitochondrial thioredoxin (Trx) system has been described as containing an NADPH-dependent Trx reductase and Trx o. In addition to the mitochondrial isoform, Trx o, plants are known to contain several chloroplastic Trx isoforms and the cytosolic Trx h isoforms. We report here the presence in plant mitochondria of a Trx isoform (PtTrxh2) belonging to the Trx h group. Western blot analy...

Journal: :Circulation 2006
Ling Tao Xiangying Jiao Erhe Gao Wayne B Lau Yuexing Yuan Bernard Lopez Theodore Christopher Satish P RamachandraRao William Williams Garry Southan Kumar Sharma Walter Koch Xin L Ma

BACKGROUND Intracellular proteins involved in oxidative stress and apoptosis are nitrated in diseased tissues but not in normal tissues; definitive evidence to support a causative link between a specific protein that is nitratively modified with tissue injury in a specific disease is limited, however. The aims of the present study were to determine whether thioredoxin (Trx), a novel antioxidant...

Journal: :Acta biochimica et biophysica Sinica 2014
Xiaoqin Zhao Yan Zhang Xiaoyu Li Ruiyuan Wang Xiangying Jiao

Cardiac complications are the leading cause of death in diabetes. However, the mechanism of diabetes in inducing myocardial injury and apoptosis, and whether the thioredoxin (Trx) system is involved remain unclear. In this study, male Sprague-Dawley rats were randomly divided into two groups: the control and the diabetes groups, and then were randomly divided into five different timepoints (the...

Journal: :American journal of physiology. Endocrinology and metabolism 2012
Yi Liu Yan Qu Rutao Wang Yanzhuo Ma Chenhai Xia Chao Gao Jingyi Liu Kun Lian Aibing Xu Xiaoyan Lu Lu Sun Lu Yang Wayne B Lau Erhe Gao Walter Koch Haichang Wang Ling Tao

The receptor for advanced glycation end products (RAGE) and thioredoxin (Trx) play opposing roles in diabetic myocardial ischemia-reperfusion (MI/R) injury. We recently demonstrated nitrative modification of Trx leads to its inactivation and loss of cardioprotection. The present study is to determine the relationship between augmented RAGE expression and diminished Trx activity pertaining to ex...

2010
Keon-Jae Park Yeon-Jeong Kim Eun Ju Choi No Kwan Park Gi Hyun Kim Sang Min Kim Sang Yeub Lee Jang-Whan Bae Kyung-Kuk Hwang Dong-Woon Kim Myeong-Chan Cho

BACKGROUND AND OBJECTIVES The thioredoxin (TRx) system is a ubiquitous thiol oxidoreductase pathway that regulates cellular reduction/oxidation status. Although endothelial cell (EC) hypoxic damage is one of the important pathophysiologic mechanisms of ischemic heart disease, its relationship to the temporal expression pattern of the TRx system has not yet been elucidated well. The work present...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2003
Jie Bai Hajime Nakamura Yong-Won Kwon Itaro Hattori Yoshimi Yamaguchi Yong-Chul Kim Norihiko Kondo Shin-ichi Oka Shugo Ueda Hiroshi Masutani Junji Yodoi

Thioredoxin (TRX) has a role in a variety of biological processes, including cytoprotection and the activation of transcription factors. Nerve growth factor (NGF) is a major survival factor of sympathetic neurons and promotes neurite outgrowth in rat pheochromocytoma PC12 cells. In this study, we showed that NGF induces TRX expression at protein and mRNA levels. NGF activated the TRX gene throu...

2017
Yichong Fan Merna Makar Michael X. Wang Hui-wang Ai

Thioredoxin (Trx) is one of the two major thiol antioxidants, playing essential roles in redox homeostasis and signaling. Despite its importance, there is a lack of methods for monitoring Trx redox dynamics in live cells, hindering a better understanding of physiological and pathological roles of the Trx redox system. In this work, we developed the first genetically encoded fluorescent biosenso...

Journal: :Biochemical and biophysical research communications 2011
Juan Carlos Fierro-González María González-Barrios Antonio Miranda-Vizuete Peter Swoboda

Dietary restriction (DR) is the only environmental intervention known to extend adult lifespan in a wide variety of animal models. However, the genetic and cellular events that mediate the anti-aging programs induced by DR remain elusive. Here, we used the nematode Caenorhabditis elegans to provide the first in vivo evidence that a thioredoxin (TRX-1) regulates adult lifespan extension induced ...

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