نتایج جستجو برای: triple helix model th collaborations involving university
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This paper introduces the concept of Triple Helix systems as an analytical construct that systematizes the key features of university-industry-government (Triple Helix) interactions into an ‘innovation system’ format defined according to systems theory as a set of components, relationships and functions. This conceptual framework offers a broad perspective for understanding the sources and deve...
PURPOSE IGF-I anti-gene technology was applied in treatment of rat and human gliomas using IGF-I triple helix approach. MATERIAL AND METHODS CNS-1 rat glioma cell and primary human glioblastoma cell lines established from surgically removed glioblastomas multiforme were transfected in vitro with IGF-I antisense (pMT-Anti-IGF-I) or IGF-I triple helix (pMT-AG-TH) expression vectors. The transfe...
The paper focuses on the link between dynamics of information and system evolution. Information, exchanged different system’s parts, before being processed is first provided with meaning by system. Meanings are generated from perspective hindsight, i.e. against arrow time. same can be differently interpreted parts (i.e. meanings) so that number options for possible development proliferated. Som...
Using a mathematical model, we show that a Triple Helix (TH) system contains self-interaction, and therefore self-organization of innovations can be expected in waves, whereas a Double Helix (DH) remains determined by its linear constituents. (The mathematical model is fully elaborated in the Appendices.) The ensuing innovation systems can be expected to have a fractal structure: innovation sys...
When two selection environments operate upon each other, mutual shaping in a coevolution along a particular trajectory is one possible outcome. When three selection environments are involved, more complex dynamics can be expected as a result of interactions involving bi-lateral and tri-lateral relations. Three selection environments are specified in the Triple Helix model: (1) wealth generation...
To investigate the role of helix formation in the folding of protein L, a 62 residue alpha/beta protein, we studied the consequences of both single and multiple mutations in the helix on the kinetics of folding. A triple mutant with 11 additional carbon atoms in core residues in the amino-terminal portion of the helix folded substantially faster than wild type, suggesting that hydrophobic assoc...
This paper is aimed to understand the role of universities in regional innovation systems in China. It particularly examines how the Chinese practices concerning the universities' engagement with the society for promoting regional innovation systems are different from the western experiences which has been often understood within the Triple Helix framework (Etzkowitz & Leydesdorff, 1995, 1997)....
w The ‘‘lock-in’’ model by Arthur Arthur, W.B., 1988. Competing technologies. In: Dosi, G., Freeman, C., Nelson, R., Ž . x Silverberg, G., Soete, L. Eds. , Technical Change and Economic Theory. Pinter, London, pp. 590–607. can be extended to the case of two and even three sources of random variation. Thus, one can model a triple helix of university–industry– government relations. In the case of...
Secondary structure elements often mediate protein-protein interactions. Despite their low abundance in folded proteins, polyproline II (PPII) and its variant, the triple helix, are frequently involved in protein-protein interactions, likely due to their peculiar propensity to be solvent-exposed. We here review the role of PPII and triple helix in mediating hostpathogen interactions, with a par...
AIMS Insulin-like growth factor type I (IGF-I) antisense cellular gene therapy of tumours is based on the following data: rat glioma or hepatoma cells transfected with the vector encoding IGF-I antisense cDNA lose their tumorigenicity and induce a tumour specific immune response involving CD8(+) T cells. Recently, using the IGF-I triple helix approach in studies of tumorigenicity, major histoco...
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