Chemokine receptors belong to the superfamily of G protein-coupled receptors, which regulate the trafficking and activation of leukocytes, and operate as coreceptors in the entry of HIV-1. To investigate the early steps in the signal transmission from the chemokine-binding site to the G protein-coupling region we engineered metal ion-binding sites at putative extracellular sites in the chemokin...

A new kind of data model has recently emerged in which the database is not constrained by a conventional schema. Systems like ACeDB, which has become very popular with biologists, and the recent Tsimmis proposal for data integration organize data in tree-like structures whose components can be used equally well to represent sets and tuples. Such structures allow great exibility in data represen...

Remnants of shooting stars are preserved in form cosmic spherules ice and sediments. The extraterrestrial material is heated melted upon atmospheric entry collected at the Earth's surface as spherules. A fraction (I-type spherules) sources from Fe,Ni metal. These metal particles melt become oxidized atmosphere. oxygen resulting oxides (magnetite, wüstite) entirely Here, we demonstrate that I-ty...

Nowadays IT and telecom worlds and specifically all network, service, and content providers show special interest in multiservice delivery. The concurrent provision of video or TV content, voice, and fast Internet via the same network and user equipment, known as ‘‘triple play service’’, constitutes one of the major concerns in modern telecommunications due to the latest developments in the are...

The synthesis, crystal structure, and characterization of a silicon–silicon triply bonded species, disilyne with two bis[bis(trimethylsilyl)methyl]isopropylsilyl substituents, are described. The nature of the sp-hybridized silicon atoms is discussed from the viewpoint of spectroscopic results and theoretical calculations. The reactivity of the disilyne with alkali metals, tBuLi, and π-bonded co...

BACKGROUND Data from large, multicenter, US studies determining the efficacy of triple therapy for the eradication of Helicobacter pylori are lacking, especially for a treatment duration of less than 14 days. METHODS Patients with H pylori infection and active duodenal ulcer disease or a history of duodenal ulcer disease within the past year were randomized to receive 30 mg of lansoprazole, 1...

Availability of integrase strand transfer inhibitors created interest in determining whether their use would decrease persistently infected cell numbers. This study hypothesized that adding raltegravir (RAL) to standard antiretroviral therapy (ART) would decrease human immunodeficiency virus (HIV)-infected CD4(+) T cells more than standard combination ART. This was a pilot, randomized study com...

The spike (S) protein of severe acute respiratory syndrome-associated CoV (SARS-CoV) mediates membrane fusion and viral entry. These events involve structural rearrangements, including heteromerization between two heptad repeats (HR1 and HR2) to form a trimer of dimers as a six-helix bundle (6-HB), a quaternary protein structure that brings two distant clusters of hydrophobic sequences into the...