نتایج جستجو برای: trigeminal ganglia

تعداد نتایج: 42267  

Journal: :Neuroscience 2010
S Eftekhari C A Salvatore A Calamari S A Kane J Tajti L Edvinsson

Calcitonin gene related peptide (CGRP) has a key role in migraine and recently CGRP receptor antagonists have demonstrated clinical efficacy in the treatment of migraine. However, it remains unclear where the CGRP receptors are located within the CGRP signaling pathway in the human trigeminal system and hence the potential antagonist sites of action remain unknown. Therefore we designed a study...

2014
Tunay Kökten Thibault Bécavin Laetitia Keller Jean-Luc Weickert Sabine Kuchler-Bopp Hervé Lesot

The sensory innervation of the dental mesenchyme is essential for tooth function and protection. Sensory innervation of the dental pulp is mediated by axons originating from the trigeminal ganglia and is strictly regulated in time. Teeth can develop from cultured re-associations between dissociated dental epithelial and mesenchymal cells from Embryonic Day 14 mouse molars, after implantation un...

2016
Man-Kyo Chung Jennifer Park Jamila Asgar Jin Y. Ro

BACKGROUND Chronic pain in masticatory muscles is a major medical problem. Although mechanisms underlying persistent pain in masticatory muscles are not fully understood, sensitization of nociceptive primary afferents following muscle inflammation or injury contributes to muscle hyperalgesia. It is well known that craniofacial muscle injury or inflammation induces regulation of multiple genes i...

Journal: :Investigative ophthalmology & visual science 1984
D E Willey M D Trousdale A B Nesburn

Iontophoresis of epinephrine into the cornea of previously infected mice was used in an attempt to induce reactivation of latent herpes simplex virus (HSV) infection of the trigeminal ganglia. BALB/c mice infected with HSV-1 strain McKrae following corneal scarification developed a latent infection of the trigeminal ganglia within 15 days. At 28 days postinfection, mice were subjected to a 3-da...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1999
G S Walsh K M Krol M D Kawaja

Sympathetic axons invade the trigeminal ganglia of mice overexpressing nerve growth factor (NGF) (NGF/p75(+/+) mice) and surround sensory neurons having intense NGF immunolabeling; the growth of these axons appears to be directional and specific (). In this investigation, we provide new insight into the neurochemical features and receptor requirements of this sympathosensory sprouting. Using do...

Journal: :Stroke 1989
K Saito M A Moskowitz

To further define the sensory projections to the circle of Willis, we measured concentrations of immunoreactive substance P in pial arteries of cats following either bilateral removal of the C1-3 dorsal root ganglia (six cats) or bilateral removal of the trigeminal ganglia (three cats). Removal of the dorsal root ganglia decreased concentrations of the tachykinin substance P in the vertebral ar...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1986
A M Davies H Thoenen Y A Barde

To determine the spectrum of activity of brain-derived neurotrophic factor (BDNF) among first-order sensory neurons, explants of the nine distinct populations of sensory neurons from embryonic chicks of 3-14 d incubation (E3-E14) were grown in collagen gels with and without BDNF in the culture medium. The explants responded to BDNF with profuse neurite outgrowth and comprised those in which neu...

Journal: :Cureus 2023

Primary central nervous system lymphoma (PCNSL) is an uncommon malignancy of B-cell origin that typically involves the brain, eyes, and spinal cord without systemic spread. PCNSL cerebral hemispheres, basal ganglia, or periventricular region. Isolated leptomeningeal any evidence parenchymal involvement very rare. We present a unusual case presenting as persistent bilateral Bell's palsy trigemin...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1998
G Middleton L G Piñón S Wyatt A M Davies

Bcl-2 is a cytoplasmic protein that blocks apoptosis in a wide variety of cell types. Here we report a novel role for Bcl-2 in the early stages of neuronal development. Shortly after differentiating from progenitor cells, sensory neurons undergo a distinct morphological change; initially they have small, spindle-shaped, phase-dark cell bodies that become large, spherical, and phase-bright. Earl...

Journal: :The Journal of Cell Biology 1993
U Arumäe U Pirvola J Palgi T R Kiema K Palm M Moshnyakov J Ylikoski M Saarma

We examined the expression of the neurotrophins (NTFs) and their receptor mRNAs in the rat trigeminal ganglion and the first branchial arch before and at the time of maxillary nerve growth. The maxillary nerve appears first at embryonic day (E)10 and reaches the epithelium of the first branchial arch at E12, as revealed by anti-L1 immunohistochemistry. In situ hybridization demonstrates, that a...

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