The cornerstone of the treatment of Wilson’s disease is a reduction of copper levels in vivo using the orallyadministered chelating agents D-penicillamine and trientine dihydrochloride. Patients with side-effects from receiving multiple blood transfusions for the amelioration of inherited anaemias are also successfully treated with chelating agents. Blood transfusion elevates these patients’ ir...

Immunoglobulin production stimulating activity of polyamines was investigated. Spermidine, thermine and triethylenetetraamine (TETA) stimulated IgM production of human-human hybridoma, HB4C5 cells under serum-free condition. IgM production of HB4C5 cells was accelerated 5.9-, 5.3-, and 3.7-fold by spermidine at 4.5 mM, thermine at 2 mM and TETA at 2.5 mM, respectively. However, putrescine did n...

In Escherichia coli, tetracycline prevents translation. When subject to tetracycline, E. coli express TetA to pump it out by a mechanism that is sensitive, while fairly independent of cellular metabolism. We constructed a target gene, PtetA-mRFP1-96BS, with a 96 MS2-GFP binding site array in a single-copy BAC vector, whose expression is controlled by the tetA promoter. We measured the in vivo k...

Nine new mononuclear and polynuclear Cu(II) complexes [Cu(H2L )Cl]Cl·3H2O (1), [Cu(H2L )Cl]Cl·H2O (2), [Cu(H2L )Cl]Cl·2.5H2O (3), [Cu3(μ -L)2(H2O)3](ClO4)2·H2O (4), [Cu4(μ-HL )4](ClO4)8·CH3OH·5H2O (5), [Cu2(HL )2](ClO4)2·2H2O (6a), [Cu2(μ-HL )2](ClO4)2·H2O (6b), [Cu2(μ-HL )(L)Cu(teta)](ClO4)3·2H2O (7) and [Cu2(H2L )2(ox)](ClO4)2·2H2O·2MeOH (8) containing [5-(2-pyridine-2-yl)-1,2,4-triazole-3-yl...

In 1995, Dell and Teta published a cohort mortality study of asbestos molding compound workers at a Union Carbide Corporation (UCC) plastics manufacturing plant in Bound Brook, New Jersey. They reported that the factory workers were exposed to "asbestos (mostly chrysotile)," implying that the asbestos used at the Bound Brook plant occasionally contained amphiboles. However, UCC statements and t...

Reaction pathway investigations of the solvothermal preparation of nanocrystalline Culn1xGa xSe2 in triethylenetetramine reveal the early formation of a previously unreported CU2-xSe(S) intermediate. Over 24 hours, this reacts with In and Se species to form CulnSe2(s). If Ga is present, the reaction proceeds over an additional 48 hours to form Culn1xGa xSe2. Adding ammonium halide salts reduces...

The importance of iron and copper in cancer biology has been well established. Iron plays a fundamental role in cellular proliferation and copper has been shown to be a significant cofactor for angiogenesis. Early observations with the chelator used for the treatment of iron overload, desferrioxamine, showed that it had promise as an anticancer agent. These results sparked great interest in the...