Tricyclic antidepressants TCAs) are no longer widely prescribed as first choice treatments for depression. In their place have come the selective serotonin reuptake inhibitors (SSRIs). Sales of SSRIs and other new antidepressants have grown massively partly at the expense of tricyclics and partly because of burgeoning antidepressant prescribing in general (Lawrenson et al, 2000; Middleton et al...

BACKGROUND Depression is a common non-motor symptom in patients with Parkinson's disease (PD). There are many kinds of antidepressants being used, such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and Dopamine agonists which are suggested as alternative antidepressants for the treatment of depress...

Tricyclic antidepressants are particularly useful in the treatment of endogenous depression. Since the 1950s, tricyclic antidepressants (TCAs) have also been used for the treatment of gastric ulcer disease. Many TCAs have been evaluated for their antiulcer effects, but there are presently no data in the literature specifically concerning the antidepressant opipramol. This study aimed to investi...

An understanding of the clinical pharmacology of antidepressant agents is essential to optimal prescribing. The following chapter outlines general principles that influence prescribing, and then discusses specific subgroups of antidepressants. There is no generally accepted classification scheme for antidepressants, and current groupings reflect marketing, the history of development, and pharma...

A previous study suggested an increased risk of preeclampsia among women treated with selective serotonin reuptake inhibitors (SSRIs). Using population-based health-care utilization databases from British Columbia (1997-2006), the authors conducted a study of 69,448 pregnancies in women with depression. They compared risk of preeclampsia in women using SSRIs, serotonin-norepinephrine reuptake i...

BACKGROUND Tricyclic and other related cyclic antidepressants (TCAs), used frequently for the treatment of depression and several other indications, have cardiovascular effects that may increase the risk of sudden cardiac death. We thus sought to quantify the risk of sudden cardiac death among TCA users, according to dose, as well as among users of selective serotonin reuptake inhibitors (SSRIs...

Tricyclic antidepressants TCAs) are no longer widely prescribed as first choice treatments for depression. In their place have come the selective serotonin reuptake inhibitors (SSRIs). Sales of SSRIs and other new antidepressants have grown massively partly at the expense of tricyclics and partly because of burgeoning antidepressant prescribing in general (Lawrenson et al, 2000; Middleton et al...

Selective serotonin reuptake inhibitors (SSRIs) have become the most popular antidepressants over the last decade, largely because they have a better side effect profile than the medications that were widely used previously, the tricyclic antidepressants (TCAs) and the monoamine oxidase inhibitors (MAOIs). The SSRIs mostly have one main mechanism of action, inhibition of serotonin reuptake. A f...

OBJECTIVE To summarize remission rates and dropouts due to adverse drug reactions (ADRs) or lack of efficacy (LoE) of serotonin-norepinephrine reuptake inhibitors (SNRIs), selective serotonin-reuptake inhibitors (SSRIs), and tricyclic antidepressants (TCAs) in treating major depressive disorder. METHODS We searched MEDLINE, EMBASE, IPA, and the Cochrane International Library from 1980-2005. M...