Triclosan antimicrobial molecular fluctuating energies of nonbonding electron pairs for the oxygen atom by ether bond rotations are reviewed with conformational computational chemistry analyses. Subsequent understanding of triclosan alternating ether bond rotations is able to help explain several material properties in Polymer Science. Unique bond rotation entanglements between triclosan and th...

Structural and genetic studies indicate that the antibacterial compound triclosan, an additive in many personal care products, is an inhibitor of EnvM, the enoyl reductase from Escherichia coli. Here we show that triclosan specifically inhibits InhA, the enoyl reductase from Mycobacterium tuberculosis and a target for the antitubercular drug isoniazid. Binding of triclosan to wild-type InhA is ...

Sir, Triclosan (2,4,4′-trichloro-2′-hydroxydiphenyl ether) is a broad-spectrum biocide that has been used for more than 30 years and can be found in a variety of household items, including toothpastes, cosmetics, antiseptic soaps, carpets, toys, floor cleaners, dishwashing detergents and even chopsticks.1,2 More recently it has been used in the clinical setting as part of a regimen for decoloni...

Triclosan, the antimicrobial agent marketed for its germ-fighting capability in personal care products, is coming under close scrutiny. In April 2010 the U.S. Food and Drug Administration (FDA) announced it is conducting a scientific and regulatory review of triclosan in FDAregulated products, with publication of results expected in spring 2011. The agency also is collaborating with the U.S. En...

Triclosan, the antimicrobial agent marketed for its germ-fighting capability in personal care products, is coming under close scrutiny. In April 2010 the U.S. Food and Drug Administration (FDA) announced it is conducting a scientific and regulatory review of triclosan in FDAregulated products, with publication of results expected in spring 2011. The agency also is collaborating with the U.S. En...

Triclosan was first introduced in the early 1970s and has been used increasingly over the past 25 years. Due to its potential to act as broad spectrum antimicrobial agent, it has been used as major ingredient in disinfectants, soap, detergent, toothpaste, mouthwash, fabric, deodorant, shampoo and innumerable other personal care, veterinary, industrial and household products. The main target of ...

Triclosan, a broad spectrum antibiotic is currently being evaluated for its anti-cancer property. Though several solvents are available to dissolve lipophilic (hydrophobic) drugs, solubility and toxicity aspects pose a challenge, when combined with the cell culture medium. In this paper, we present a simple approach based on physico-chemical and biologic criteria to choose a suitable solubilizi...

Triclosan, the antimicrobial agent marketed for its germ-fighting capability in personal care products, is coming under close scrutiny. In April 2010 the U.S. Food and Drug Administration (FDA) announced it is conducting a scientific and regulatory review of triclosan in FDAregulated products, with publication of results expected in spring 2011. The agency also is collaborating with the U.S. En...

There is a disinfectant showing up in hundreds of common consumer products that is raising serious cause for concern. The chemical, triclosan, is a synthetic, broad-spectrum antimicrobial agent that in recent years has exploded onto the consumer market in a wide variety of antibacterial soaps, deodorants, toothpastes, cosmetics, fabrics, plastics, and other products. Studies have increasingly l...

The biocide triclosan is used in many personal care products, including toothpastes, soaps, clothing, and medical equipment. Consequently, it is present as a contaminant in the environment and has been detected in some human fluids, including serum, urine, and milk. Staphylococcus aureus is an opportunistic pathogen that colonizes the noses and throats of approximately 30% of the population. Co...