A combination of MICs of an N-chloramine, a simple chlorinated amino acid, and diazolidinyl urea gave synergistic activity against bacteria, but not fungi. The two compounds at a higher concentration, 0.1 and 0.3%, respectively, gave synergistic inhibition of fungi; kill times were 1 h for Trichophyton tonsurans, 3 h for Aspergillus niger and Fusarium moniliforme, and 6 h for Aspergillus fumiga...

OBJECTIVES Arthroconidia have been considered as the primary cause of infection by dermatophytes. However, the in vitro antifungal testing evaluates the responses mainly of microconidia or hyphae, and dermatophytes in vivo often produce arthroconidia, a cellular structure presumably more resistant to antifungals. The aim of this study was to compare the in vitro susceptibility of microconidia a...

Peganum harmala (Zygophyllaceae) is an intriguing herb with a long history of medicinal use. Antifungal activity of P. harmala seed extract against certain fungal species was investigated in vitro. Antifungal activity of the extract of P. harmala seeds was investigated against several fungal species using in vitro agar dilution technique. The fungal species included: Microsporum canis, Microspo...

Peganum harmala (Zygophyllaceae) is an intriguing herb with a long history of medicinal use. Antifungal activity of P. harmala seed extract against certain fungal species was investigated in vitro. Antifungal activity of the extract of P. harmala seeds was investigated against several fungal species using in vitro agar dilution technique. The fungal species included: Microsporum canis, Microspo...

Tinea capitis is a condition usually found only in children. However, its epidemiological profile has changed in recent decades, with regard to age at onset and the causative microorganisms. We report the cases of 4 women over 65 years of age diagnosed with tinea capitis. One presented plaques of alopecia with desquamation and the other 3 developed crusted inflammatory lesions. Cultures were po...

A rapid two-step DNA extraction method and a multiplex PCR for the detection of dermatophytes in general and Trichophyton rubrum specifically were developed and evaluated with DNA extracted from pure cultures and from clinically diseased nails. DNA from the following dermatophytes was used: Epidermophyton floccosum, Microsporum audouinii, Microsporum canis, Microsporum gypseum, Microsporum nanu...