The randomized clinical trial is the preferred research design for evaluating competing diagnostic and therapeutic alternatives, but confidence in the conclusions from a randomized clinical trial depends on the authors' attention to acknowledged methodologic and statistical standards. This survey assessed the level of attention to the problem of multiple comparisons in the analyses of contempor...

BACKGROUND: Evidence-based medicine demands the use of information from clinical trials to direct medical care. Knowledge of the principles of trial design and conduct is important to assess the validity of results. METHODS: The authors review the key principles behind clinical study design and conduct, and they summarize important biases and confounding issues. RESULTS: Clear hypotheses, a wel...

Background Clinical trials are known as the most valid medical research. It is able to promote medical evidences on prevention, diagnosis, screening, treatment, and quality of life because in this type of study, an intervention is intentionally performed on subjects. Therefore, it encompasses ethical concerns and considerations, especially when human subjects are studied. In other words, clinic...

this study was conducted to investigate the effect of replacing barley with different levels of ground date seeds (gds) in the diet (0, 15, 3o and 45%) on performance of local growing male goats. sixteen local male kids (average live weight 16.1±1.41 kg) were allocated randomly to four treatments (4 animal/treatment). the trial consisted of a 14 day acclimatization period followed by a 60-day m...

the aim of this study was to evaluate blocked, random, gradual incremental and gradual decremental practice schedules on the acquisition and retention of different types of basketball pass (overhead, hand chest , single arm with dominate hand) in 8-10-year-old girls. for this purpose, 60 female students of second, third and fourth grade of elementary school were voluntarily selected and randoml...

according to the holy qur'an, human life is intermingled with trials, having a mutual relationship with man's perfection and elevation. as objective models of divine trials, prophets are chosen and reported intelligently in the qur'an. the central issue in this research is to draw a revealed pattern of the trial of prophets and analyze its components, emphasizing on the story of ...

Prasaplai is used in Thai traditional medicine for treatment of primary dysmenorrhea; however, clinical evidence is limited regarding the efficacy of Prasaplai for primary dysmenorrheal outcomes. This study has constituted a systematic review and meta-analysis to evaluate Prasaplai as an effective treatment for primary dysmenorrhea. Randomized controlled trials were retrieved and identified thr...