Epilepsy is a common neurological disorder characterized by seizure and loss of neuronal cells by abnormal rhythmic firing of neurons in the brain. In the present study, we investigated the effect of treadmill exercise on gamma-aminobutyric acid (GABA)ergic neuronal loss in relation with neuronal activation using pilocarpine-induced epileptic rats. The rats were divided into four groups: contro...

Instrumented treadmills offer significant advantages for analysis of human locomotion, including recording consecutive steady-state gait cycles, precisely controlling walking speed, and avoiding force plate targeting. However, some studies of hemiparetic walking on a treadmill have suggested that the moving treadmill belt may fundamentally alter propulsion mechanics. Any differences in propulsi...

Patients with Parkinson's disease (PD) improve gait after treadmill training and while they are walking over the treadmill. However, the mechanisms of these improvements have not been addressed. We designed a treadmill simulator without a belt that could move on a walkway in a constant speed, in order to explore the mechanism underlying treadmill walking improvements in PD. All subjects were te...

In recent years, the increase in obesity world has led to development of new strategies combating obesity. present study, it was aimed investigate effect niacin and melatonin supplements combat rats as a model organism. Treadmill exercise performed on after supplementation for 10 days. each group, weight loss observed at end days exercise. this that leading had treadmill when compared control g...

Gait disturbances are one of the principal and most incapacitating symptoms of Parkinson's disease (PD). In addition, walking economy is impaired in PD patients and could contribute to excess fatigue in this population. An important number of studies have shown that treadmill training can improve kinematic parameters in PD patients. However, the effects of treadmill and overground walking on th...

Alzheimer disease (AD) is a most common form of dementia and eventually causes impairments of learning ability and memory function. In the present study, we investigated the effects of treadmill exercise on the symptoms of AD focusing on the microglial activation-induced apoptosis. AD was made by bilateral intracerebroventricular injection of streptozotocin. The rats in the exercise groups were...

Time limited exercise on a self powered treadmill was evaluated as a method of assessing functional capacity in patients with mild heart failure. The characteristics of the treadmill were established by exercising 11 controls at three speeds and two inclinations and comparing oxygen consumption with that on a motorised treadmill under the same conditions. Oxygen consumption on the self powered ...

OBJECTIVE The objective of this study is to assess the cost/value tradeoff of a routine treadmill requirement for life insurance applicants. For this purpose, we are interested in the treadmill's ability to provide unique information on the mortality risk in a population of apparently healthy and asymptomatic individuals, as opposed to the treadmill done for diagnostic or confirmatory purposes....

background: the present study evaluated the effects of treadmill running on extracellular basal levels of glutamate and gaba at dentate gyrus of streptozotocin-induced diabetic rats. methods: after 12 weeks of diabetes induction and exercise period, extracellular levels of glutamate and gaba were investigated. results: the results showed that glutamate levels were significantly decreased in dia...

Gait timing dynamics of treadmill and overground running were compared. Nine trained runners ran treadmill and track trials at 80, 100, and 120% of preferred pace for 8 min. each. Stride time series were generated for each trial. To each series, detrended fluctuation analysis (DFA), power spectral density (PSD), and multiscale entropy (MSE) analysis were applied to infer the regime of control a...