Introduction: Following a traumatic brain injury (TBI), the excessive release of proinflammatory cytokines is major cause of cerebral edema that can cause permanent neuronal loss. This study examined the changes in brain concentrations of proinflammatory cytokines IL-1, IL-6, TNF-α and TGF- after different doses of estrogen or progesterone treatment in brain-injured rats at 6 and 24 h post...

Head injury is among the most devastating types of injury, specifically called Traumatic Brain Injury (TBI). There a need to diminish morbidity related with TBI and improve outcome patients suffering TBI. Among improvements in treatment TBI, neuroprotection one upcoming improvements. Citicoline has been used management brain ischemia disorders, such as biochemical, pharmacological, pharmacokine...

Traumatic brain injury (TBI) is a significant public health concern in our country, because of placing in top three most common causes of death and substantial direct and indirect costs to society. The incidence of TBI in our country is 1.7 times of international incidence. Traumatic brain injury induced by primary and secondary mechanisms that give rise to death and neurologic morbidity in pat...

Abstract Purpose of Review Early enteral nutrition improves outcomes following traumatic brain injury (TBI). This can prove difficult due to TBI-induced feeding intolerance secondary disruption the brain-gut axis, a network composed central nervous system (CNS) input, autonomic signaling, and immunologic regulation that controls gut CNS homeostasis. Here, we discuss pathophysiology brain–gut ax...

Background: The present study assesses independent predictors of clinically important traumatic brain injury (ciTBI) in order to design a prognostic rule for identification of high risk children with mild head injury. Materials and Methods: In a retrospective cross-sectional study, 3,199 children with mild traumatic brain injury (TBI) brought to emergency ward of three hospitals in Tehran, Iran...

traumatic brain injury (tbi) is an important cause of death and disability in young adults ,and may lead to physical disabilities and long-term cognitive, behavioral psychological and social defects. there is a lack of definite result about the effect of thyroid hormones after traumatic brain injury in the severity and no data about their effect on mortality of the injury. the aim of this study...

traumatic brain injury (tbi) is a common injury leading to child disability and is associated with a variety of long-term cognitive, social, and behavioral dysfunctions. emotion perception (ep) starts up an integral part of social communication is critical to achieve developmentally appropriate goals. this skill, which emerges relatively early in development, is driven by increasing connectivit...

objective(s): brain edema is one of the most serious causes of death within the first few days after trauma brain injury (tbi). in this study we have investigated the role of shilajit on brain edema, blood-brain barrier (bbb) permeability, intracranial pressure (icp) and neurologic outcomes following brain trauma.   materials and methods: diffuse traumatic brain trauma was induced in rats by dr...

traumatic brain injury (tbi) is caused by rapid deformation of the brain, resulting in a cascade of pathological events and ultimately neurodegeneration. in vitro models of tbi can help us to describe the pathobiological mechanisms. in vitro models of brain injury support a platform for performing repeatable, well-controlled, environmentally isolated experiments. other advantages of in vitro mo...