background patients with thalassemia major and intermedia are susceptible to osteopenia and osteoporosis. the mechanism of osteoporosis in these patients is multifactorial. transfusion related iron overload in endocrine organs leads to impaired growth hormone secretion, diabetes mellitus, hypothyroidism, hypoparathyroidism, lack of sex steroids and vitamin d deficiency that contribute to impair...

The effect of Vitamin E and N-acetyl cysteine on oxidative status hemoglobin level in transfusion-dependent thalassemia patients: A systematic review meta-analysis

background and purpose: despite extensive research on family planning and education, reproductive behavior of high-risk couples for thalassemia remains a major concern among medical professionals. this study aimed to evaluate the knowledge and attitude of carrier couples for transfusion-dependent thalassemia major (tdtm). methods: this case-control study was conducted 327 carrier couples for th...

BACKGROUND Iron overload is the main transfusion related side effects in patients with transfusion dependent hemoglobinopathies. Severe iron deposition in tissues leads to organ dysfunction. Many organs can be affected such as heart, liver, and endocrine organs. Cardiac failure and liver fibrosis are the consequent of Iron overload in transfusion dependent hemoglobinopathy. Magnetic Resonance I...

Background: Thalassemia is an inherited disease. major patients are transfusion-dependent and very much prone to transfusion-transmitted viral infections. So, this study was conducted determine the prevalence various determinants, contributing in blood transfusion transmitted infection among them. Methodology: A 12-month longitudinal research on thalassemia who met inclusion criteria were regis...

background: increased costs and mortality associated with inappropriate blood transfusions have led to investigations about blood request and blood transfusion techniques. we investigated the transfusion status in patients who underwent orthopedic surgery in poursina hospital (rasht, iran) to optimizing blood usage and determine if a scheduled transfusion program for every orthopedic surgery co...