Abstract

A longstanding challenge in production chemistry is the development of catalytic methods for the transformation of carbon dioxide into useful chemicals. Silane and borane promoted reductions can be fined-tuned to provide a number of C1-building blocks under mild conditions, but these approaches are limited because of the production of stoichiometric waste compounds. Here we report on the conver...

The LC-UV, LC-MS and CE-UV study of chemical reaction between captopril and p-bromophenacyl bromide as derivatizing reagent is reported. During transformation of captopril, its thiol group is involved and the reaction is irreversible. Neutral or alkaline environments favor derivatization. The yield of reaction increases linear with the concentration of the reagent, while changes in temperature ...

The dihalogenation of alkenes is one the classic reactions in organic chemistry and a prime example an electrophilic addition reaction. often observed anti-selectivity this reaction can be explained by formation haliranium-ion intermediate. Although dihalogenations have been studied for more than century, development reagent-controlled, enantioselective has proved to very difficult. Only recent...

Grignard reagents (R-Mg-X) are commercial carbon nucleophiles commonly used in organic synthesis, but their stability becomes a limitation for the least-reactive electrophiles. A bulky magnesium anilide additive (in purple) generates new organometallic reagent (R−Mg-NHAr) situ that boosts nucleophilicity and selectivity of ligand green). In Research Article by A. Mendoza co-workers (DOI: 10.100...

Cycle-linear hybrid automata (CLHAs), a new model of excitable cells that efficiently and accurately captures action-potential morphology and other typical excitable-cell characteristics such as refractoriness and restitution, is introduced. Hybrid automata combine discrete transition graphs with continuous dynamics and emerge in a natural way during the (piecewise) approximation process of any...

A series of glycosyl hemiacetal derivatives have been transformed into thioglycosides and glycosyl thiols in a one-pot two-step reaction sequence mediated by Appel reagent (carbon tetrabromide and triphenylphosphine). 1,2-trans-Thioglycosides and β-glycosyl thiol derivatives were stereoselectively formed by the reaction of the in situ generated glycosyl bromides with thiols and sodium carbonotr...

organophosphorus compounds are known to inhibit the esteratic site of acetylcholinesterase by phosphorylation. the phosphorylated esteratic site of acetylcholinesterase undergoes hydrolytic regeneration at a slow or negligible rate. nucleophilic agents such as hydroxytamine, hydroxamic acids, and oximes reactivate the enzyme more erapidfy than does spontaneous hydrolysis. the red cell cholinest...