Topically applied pharmaceuticals in the form of patches that distribute medications for systemic effects at predefined and controlled rates are known as "transdermal drug delivery systems." The main function TDDS is penetration through skin. It works extremely simple, with medicine being put within patch placed on As a result, consistent concentration medication remains bloodstream an extended...

Transdermal drug delivery system offers best way of through skin than compared to oral route administration by overcoming side-effects.Drug is done adhesion transdermal patches surface.Novel application techniques have been employed for better therapeutic response various in treatment several disease using dermal administration.This non-invasive method reducing frequency achieve complete action...

The present article is a descriptive study of the performances of ethosomes and proniosomes as specialized delivery systems for transdermal drug delivery system. Vesicular systems, such as ethosomes and proniosomes are used in cosmetic and pharmaceutical products to encapsulate ingredients, to protect ingredients from degradation, to increase bioavailability, and to improve cosmetic performance...

212 P&T® • April 2008 • Vol. 33 No. 4 ABSTRACT Although monoamine oxidase inhib itors (MAOIs) at one time represented the mainstay of therapy for major depressive disorder (MDD), the risk of acute hypertensive reactions following the ingestion of tyramine-rich foods and the consequent need to restrict dietary tyramine represent a barrier to their use. In this article, we present an overview of ...

Microemulsions have received great attention for applications in transdermal drug delivery. The use of curcumin for treating various skin diseases like scleroderma, psoriasis, and skin cancer was extensively reported. The solubility of curcumin in various oils, surfactants, and cosurfactants was studied herein in order to find the optimal components for a transdermal delivery vehicle. Microemul...

   Repeated oral administration of mexazolam, an anti-anxiety agent, may cause adverse effects such as gastric disturbance, drowsiness, and ataxia due to transiently high blood levels. Transdermal administration would avoid the systemic side effects and gastric disorders after oral administration. We have developed a matrix using ethylene-vinyl acetate (EVA), a heat-processible and flexible mat...

Transdermal delivery holds a promising carrier in the transport of drugs to get direct access across the skin deep into the systemic circulation.. It has attracted many researchers due to various biomedical advantages. The barrier nature of stratum corneum poses a threat to the drug delivery. However, various attempts have been made to modify this property of the skin and thus, to improve the t...