objective: patients over 60 years of age have higher mortality and morbidity after major liver resections. nitric oxide (no) derived from the catalytic activity of nos2 plays a beneficial role in liver regeneration (lr) after partial hepatectomy (ph). in this experiment, we evaluated the effect of nos2 knockout (ko) on lr in aged mice after ph. materials and methods: in this cohort study, 52 tw...

Recently, host whole blood gene expression signatures have been identified for diagnosis of tuberculosis (TB). Absolute quantification the concentrations signature transcripts in not reported, but would facilitate diagnostic test development. To identify minimal transcript signatures, we applied a selection procedure to microarray data from African adults comprising 536 patients with TB, other ...

The vertebrate genome contains large spans of non-coding RNA, which for the most part were considered of little functional value to the organism. Recent studies have indicated that vertebrate genomes may have stored hidden secrets in this large span of non-coding RNA, which we refer to here as "Natural Antisense Transcripts (NATs)." NATs can be found in introns, exons, promoters, enhancers, int...

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The following is a transcript of the Q&A with Zoё Seaton on 2 August 2022.

in this study, accumulation of h2o2, malondialdehyde (mda) (as cold-induced oxidative stress indicators), the transcript levels of dehydrin and beta-glucosidase genes (involved in metabolic responses) was evaluated in chickpea cv. jam, using qrt-pcr during control, cold acclimation (ca), cold stress (cs), recovery, and freezing phases. results showed the existence of wide range of genetic capac...

Background: Leptin, the product of the obesity (ob) gene, acts as a signaling adipokine for modulating food intake, energy metabolism and reproductive functions in mammals. Leptin’s effects on the reproductive system at various levels of the hypothalamic-pituitary-gonadal axis have been established. Moreover, the direct and local effect of leptin on bovine oocyte maturation and corpus luteum fu...

The cytogenetic hallmark of Chronic Myeloid Leukemia (CML) is the presence Philadelphia (Ph) chromosome, which results from a reciprocal translocation t(9;22)(q34;q11). In this report, we describe CML patient with no evidence Ph chromosome but trisomy 8 as single abnormality and typical e14a2 (b3a2) BCR-ABL1 fusion transcript. Fluorescence Situ Hybridization (FISH) analysis revealed an uncommon...