trans-Resveratrol is often considered as one of the quality standards of red wine, and the development of a sensitive and reliable method for monitoring the trans-resveratrol levels in red wine is an urgent requirement for the quality control. Here, a novel voltammetric approach was described for probing trans-resveratrol using a graphene-modified glassy carbon (GC) electrode. The proposed elec...

trans-Resveratrol (3,5,4'-trihydroxy-trans-stilbene) has been reported to confer chemoprotection against 7,12-dimethylbenz[a]anthracene (DMBA)-induced carcinogenicity in a murine model. A potential mechanism for this effect by trans-resveratrol is inhibition of DMBA-bioactivating cytochrome P450 (CYP) enzymes such as CYP1B1, CYP1A1, and CYP1A2. In the present study, we examined in detail the in...

the stimulation of nitric oxide generation (Gresele et al., 2008), and the modulation of signaling molecules such as protein kinase C (Yang et al., 2008b), phospholipase C (Yang et al., 2008a), p38 MAPK (Shen et al., 2007). Resveratrol exists as either the trans-isomer [(E)-resveratrol, 5-{(E)-2-(4-hydroxyphenyl)ethenyl}benzene-1,3-diol; CAS Number 501-36-0] or cis-isomer [(Z)-resveratrol, 5-{(...

Back Cover: Polymer networks are synthesized to selectively target trans-resveratrol. By employing a statistical design of experiments, the polymerizations conducted using ultraviolet light initiation, thus yielding materials with molecularly imprinted binding sites tailored for These successfully applied in purifying trans-resveratrol from winemaking residues, demonstrating their practical uti...

Abstract Premature ovarian insufficiency (POI) is a clinical syndrome defined by loss of activity before the age 40 years and characterized menstrual disturbance, follicle stimulating hormone (FSH) concentration above IU/l infertility. In some patients best option to conceive spontaneously since many treatment strategies remain unsuccessful or involve eggs donation. this case report series, we ...

Cardiac troponin, a heterotrimeric protein complex that regulates heart contraction, represents an attractive target for the development of drugs for treating heart disease. Cardiovascular diseases are one of the chief causes of morbidity and mortality worldwide. In France, however, the death rate from heart disease is remarkably low relative to fat consumption. This so-called "French paradox" ...

We investigated the effects of a high-protein diet and resveratrol supplementation on immune cells changes induced by abdominal irradiation in rats. Female Wistar rats were divided into 5 groups: 1) control diet, 2) control diet with irradiation 3) 30% high-protein diet with irradiation, 4) normal diet with resveratrol supplementation and irradiation, and 5) 30% high-protein diet with resveratr...

The mode of action of trans-resveratrol, a promising lead compound for the development of neuroprotective drugs, is unknown. Data from a functional genomics study were retrieved with the aim to find differentially expressed genes that may be involved in the benefits provided by trans-resveratrol. Genes that showed a significantly different expression (p<0.05, cut-off of a two-fold change) in mi...

(Effects of trans-resveratrol and dimethyl sulfoxide on intermediate metabolism and lipoperoxidation in Drosophila melanogaster). Many plants contain the phytoalexin trans-resveratrol. Red grapes and peanuts are rich in this antioxidant which is thought to be responsible for the reported protective effect of wine against diseases and also the ability to retard aging. We investigated the effects...