The kinetics of excretion of the novel tranquilizer cinazepam (3-hydroxy-7-bromo-5-(ortho-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one hemisuccinate (I)) in mice after a single administration and different schemes of multiple administration were determined. Mass balance was studied daily in excretions of mice (feces and urine) for 5-10 days. We observed that monoexponential renal excreti...

This study examined the relationship between past-year drinking behaviors and nonmedical use of prescription drugs (NMUPD) in a nationally representative sample. Prevalence estimates in the United States were derived based on data collected from face-to-face interviews using the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) (n=43,093 individuals aged 18 years and olde...

OBJECTIVE We examined the prevalence and correlates of prescription drug misuse (PDM) in a population-based sample of adults from Alberta. METHODS Data were collected from 3511 adults in Alberta aged 18 years and older in 2002 using a computer-aided telephone survey; the survey response rate was 57.4%. RESULTS The prevalence of 12-month PDM in Alberta was 8.2% in 2002. Opiates were the most...

Many epilepsy patients, particularly those with complex partial seizures, also develop psychiatric disorders during the course of their illness and have to be treated with psychotropic drugs in addition to their antiepileptic medication. However, the brains of epileptic patients can be considered pathologically altered and psychotropic drugs may thus have profound and stronger effects on seizur...

exposure to the depression of our patients makes us more vulnerable. Where the doctor feels threatened by the patient's depression, and especially if this reaction is an unconscious one, he is likely to try to protect himself by getting rid of the patient. He may do this by putting him on medication, not as an adjunct, but as an alternative to exploration of the problem. Or, if at all alarmed, ...

This study was performed on a representative sample of the Danish population in order to investigate the connection to the use of psychoactive drugs and quality of life (QOL) by way of a questionnaire-based survey. The questionnaire was mailed in February 1993 to 2,460 persons aged between 18 and 88, randomly selected from the CPR (Danish Central Register), and 7,222 persons from the Copenhagen...

• Large animals have been used on numerous occasions by investigators pioneering in the field of cardiovascular research. The first recorded measurement of arterial blood pressure was made in the horse by Stephen Hales in .1733. Cardiac catheterization was first performed in a horse by Chauveau and Marey in 1861. One of the earliest applications of the Fick principle to the measurement of cardi...

• Large animals have been used on numerous occasions by investigators pioneering in the field of cardiovascular research. The first recorded measurement of arterial blood pressure was made in the horse by Stephen Hales in .1733. Cardiac catheterization was first performed in a horse by Chauveau and Marey in 1861. One of the earliest applications of the Fick principle to the measurement of cardi...

Chronic deteriorated patients have been receiving increased attention since the advent of the tranquilizing drugs. The problem of evaluating the effects of these drugs on this type of patient has become acute. Recently the authors were called upon to evaluate the therapeutic effects of a new drug, promazine, on such patients (4). The existing scales seemed ill-suited for use at this very low le...