This paper reports on the therapeutic use of tranexamic acid in an elderly patient with severe comorbidities that precluded even endovascular reintervention. Orally administered tranexamic acid mitigated and partially reversed two and a half years of progressive aneurysmal expansion and closed a persistent endoleak after thoracic endovascular aneurysm repair and endovascular aneurysm repair for...

background: the most appropriate route of tranexamic acid administration is controversial. in the current study, we compared the efficacy of intravenous (iv) and topical intra-articular tranexamic acid in reducing blood loss and transfusion rate in patients who underwent primary total knee arthroplasty. methods: one hundred twenty 120 patients were scheduled to undergo primary total knee arthro...

The effects of intravenous tranexamic acid were compared with placebo in 64 patients with subarachnoid hemorrhage. A double-blind procedure was used. One gram of tranexamic acid was given intravenously every 4 hours up to the time of operation on an intracranial arterial aneurysm or for up to 21 days after the first bleeding if operative treatment was not feasible. There were no differences in ...

OBJECTIVE To assess the efficacy of tranexamic acid or mefenamic acid in the management of the initial "nuisance" bleeding or spotting in the period immediately after placement of the levonorgestrel-releasing intrauterine system. METHODS Women were randomized after levonorgestrel-releasing intrauterine system placement to oral tranexamic acid (500 mg), mefenamic acid (500 mg), or placebo thre...

BACKGROUND Although the impact of tranexamic acid on platelet function remains controversial, tranexamic acid is part of clinical algorithms for the management of platelet dysfunction. The goal of our prospective, observational study was to examine the effects of tranexamic acid on platelet function in patients treated with dual antiplatelet therapy compared to those who ceased antiplatelet the...

introduction: traumatic brain injury is considered as the major cause of mortality and hospitalization of about ten million people across the globe. most of these patients are young and active people suffering disabilities. tranexamic acid (txa) therapy is commonly used to reduce blood loss and need for blood transfusions in surgical cases. this study aimed at investigating the effect of tranex...

background: we sought to determine the efficacy of topical tranexamic acid (5%) in the management of traumatic hyphema. methods: thirty eyes with gross traumatic hyphema were enrolled in this study. the patients were treated with tranexamic acid (5%) eye drop every 6 hours for 5 days. the main outcome measures were best corrected visual acuity (bcva), intra-ocular pressure (iop), day of clot ab...

OBJECTIVE To determine the effectiveness and safety of perioperative tranexamic acid use in patients undergoing total hip or knee arthroplasty in the United States. DESIGN Retrospective cohort study; multilevel multivariable logistic regression models measured the association between tranexamic acid use in the perioperative period and outcomes. SETTING 510 US hospitals from the claims based...

background intrauterine device (iud) is a safe and efficient method for preventing pregnancy favored by many women. menorrhagia is the most common complication of using copper iud. we aimed to compare the effect of tranexamic acid and mefenamic acid on the reduction of copper iud-induced menorrhagia. methods in this randomized controlled trial, 84 women who were using iud (tcu-380) with complai...

Melasma is a localized, chronic acquired hypermelanosis of the skin. Despite several treatments available, melasma can often be refractory to treatment. Also recurrences are common. Tranexamic acid is a new addition in treatment of melasma and is effective in dosage of 250 mg BD for atleast 4 to 8 weeks. Tranexamic acid acts mainly via the plasminogen activator-plasmin system to prevent UV radi...