The first enantioselective total synthesis of a member of the okaramine family of bis-indole alkaloids, okaramine N (1), has been accomplished via intermediates 2-7, as outlined. The N-prenylated derivative of (S)-tryptophan methyl ester (2) was coupled with Fmoc-protected N-tert-prenylated tryptophan (3) to form the amide 4 in 70% yield. Pd(II)-mediated cyclization/rearrangement, a key step in...

This paper reports on a comparative case study of 13 industrial firms that implemented an enterprise resource planning (ERP) system. It compares firms based on their dialectic leaming process. All firms had to overcome knowledge barriers of two types: those associated with the configuration of the ERP package, and those associated with the assimilation of new work processes. We found that both ...

Authors’ Affiliations: Departments of 1 Hematology/Oncology, Medicine, 2 Pathology & Laboratory Medicine, 3 Biochemistry and Molecular Biology, 4 Internal Medicine, and 5 Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, 6 VA Staff Physician, Research Service, Ralph H. Johnson VAMC, Charleston, South Carolina, and 7 University of Hawaii Cancer Center, Hon...

Discussed at the meeting “Focus on Primary Care Management of Depression,” October 15–16, 1998, in Charleston, S.C., held by the International Consensus Group on Depression and Anxiety. The Consensus Meeting was supported by an unrestricted educational grant from SmithKline Beecham Pharmaceuticals. Reprint requests to: James C. Ballenger, M.D., Medical University of South Carolina, Department o...

Organizers Ann English, Department of Chemistry and Biochemistry, Concordia University, Montreal, H3G 1M8, Canada; Phone: 514-848-3338; Fax: 514-848-2868; Email: [email protected] Ichiro Okura, Department of Bioengineering, Tokyo Institute of Technology, Yokohama, Japan; Phone: 045-924-5752; Fax: 045-924-5778 Shigenobu Yano, Department of Chemistry, Nara Women’s University, Nara, Japan;...