In this study, the interactions of enterohemorrhagic Escherichia coli (EHEC) O157 strains with human ileocecal (HCT-8) epithelial cells and HEp-2 cells were examined. EHEC adhered to, but did not invade, HCT-8 cells by the localized adherence mechanism and a heretofore unrecognized pattern which we called log jam. The log jam formation was (i) not observed on HEp-2 cells, (ii) independent of th...

OBJECTIVE Although junctional adhesion molecule (JAM)-C has been implicated in the control of inflammatory leukocyte recruitment, its role in neointima formation after arterial injury has not been elucidated. METHODS AND RESULTS In apolipoprotein E-deficient (Apoe(-/-)) mice fed an atherogenic diet, antibody blockade of JAM-C significantly reduced neointimal hyperplasia after wire injury of c...

We have investigated the contribution of the tight junction (TJ) transmembrane protein junction-adhesion-molecule 1 (JAM-1) to trophectoderm epithelial differentiation in the mouse embryo. JAM-1-encoding mRNA is expressed early from the embryonic genome and is detectable as protein from the eight-cell stage. Immunofluorescence confocal analysis of staged embryos and synchronized cell clusters r...

We report how the Global Game Jam was introduced in Japan. Introducing events like the Global Game Jam can assist in promoting the benefits of new methods and technologies to the developers, educators, and students throughout the world. In our case, many Japanese jam attendees were not well-acquainted with the practice of the participatory design or prototyping well before the Global Game Jam. ...

Several saffron ecotypes (Mashhad, Torbat-Jam, Torbat-Haydarieh, Gonabad, Birjand, Ghaen) were evaluated in Urmia for stigma yield and yield components using different maternal corm weights(6, 8, 10, 12 g) in 2013 cropping year. The experiment was arranged as factorial based on randomized complete block design. Analysis of variance showed that there were significant differences among saffron ec...

BACKGROUND Junctional adhesion molecule (JAM)-A expressed in endothelial, epithelial, and blood cells can regulate permeability and leukocyte extravasation. Atherosclerosis develops at sites of disturbed flow in large arteries, but the mechanisms guiding inflammatory cells into these predilection sites remain unknown. METHODS AND RESULTS To characterize cell-specific functions of JAM-A in ath...

OBJECTIVE Spiritual beliefs can help people find meaning of life, and can also influence their feelings, behaviors and mental health. The present research studied the relationship between basic religious beliefs (Human, Existence and God) and five personality factors: neuroticism, extraversion, openness, agreeableness, conscientiousness. METHOD One hundred seventy eight students of Islamic Az...

Objective—Although junctional adhesion molecule-A (JAM-A) has recently been implicated in leukocyte recruitment on early atherosclerotic endothelium and after reperfusion injury, its role in neointima formation after arterial injury remains to be elucidated. Methods and Results—Here we show that the genetic deletion of JAM-A in apolipoprotein E–deficient (apoE / ) mice significantly reduced neo...

OBJECTIVE Although junctional adhesion molecule-A (JAM-A) has recently been implicated in leukocyte recruitment on early atherosclerotic endothelium and after reperfusion injury, its role in neointima formation after arterial injury remains to be elucidated. METHODS AND RESULTS Here we show that the genetic deletion of JAM-A in apolipoprotein E-deficient (apoE(-/-)) mice significantly reduced...