BACKGROUND Aloe vera is a natural product that is frequently used in soothing skin care products such as aftersun lotions. In the present study we aimed to explore the anti-inflammatory potential of a highly concentrated A. vera gel in the UV erythema test in vivo. METHODS 40 volunteers with skin types II and III were included in the randomized, double-blind, placebo-controlled, phase III mon...

Tacrolimus ointment, a topical inhibitor of the phosphatase calcineurin, has recently been approved in the United States for use in the treatment of atopic dermatitis. It is the first topical immune suppressant that is not one of the hydrocortisone derivatives, important allies in dermatology for nearly 50 years. Although tacrolimus is less able to penetrate thick skin than glucocorticoids, it ...

abstractpaederus dermatitis is an irritant contact dermatitis due to accidental contact by a beetle belonging to the genus paederus. in this study, clinical efficacies of s. ebulus fruit extract solution in patients affected by paederus dermatitis were evaluated. a randomized double-blind, prospective, placebo-controlled clinical trial was performed in 62 patients with clinical symptoms and sin...

Bendazac or 1-benzyl-indazole 3-oxyacetic acid is a topical antinflammatory drug which in previous experiments was shown to preferentially inhibit inflammatory processes progressing towards necrosis (1). This activity has been temptatively related to a pre vention of protein denaturation (2-4). The aim of these experiments was to study effects of bendazac and hydrocortisone on heat-induced burn...

Several corticosteroids, such as prednisolone, dexamethasone and hydrocortisone/cortisol, are prescribed to suppress inflammation in a range of conditions. This article aims to update knowledge and encourage a review of practice. The emphasis will be on monitoring the adverse effects of medication and on patient education. After reading this article you should be able to: Explain the rationale ...

■ Evidence summary A recent meta-analysis included 25 randomized controlled trials involving tacrolimus and pimecrolimus. This review included trials of tacrolimus and pimecrolimus in comparison with placebo, topical corticosteroids of varying strengths, and each other. They reported on both safety and efficacy. Fifteen vehiclecontrolled trials of pimecrolimus and tacrolimus were reviewed. Both...

AbstractPaederus dermatitis is an irritant contact dermatitis due to accidental contact by a beetle belonging to the genus paederus. In this study, clinical efficacies of S. ebulus fruit extract solution in patients affected by paederus dermatitis were evaluated. A randomized double-blind, prospective, placebo-controlled clinical trial was performed in 62 patients with clinical symptoms and sin...

AbstractPaederus dermatitis is an irritant contact dermatitis due to accidental contact by a beetle belonging to the genus paederus. In this study, clinical efficacies of S. ebulus fruit extract solution in patients affected by paederus dermatitis were evaluated. A randomized double-blind, prospective, placebo-controlled clinical trial was performed in 62 patients with clinical symptoms and sin...

Since their introduction, topical corticosteroids have become indispensable in the treatment of various dermatoses. Hydrocortisone was the first compound. Modifications in the basic structure generated in vivo activity and thus different topically active compounds were discovered. Apart from the Stoughton vasoconstrictor assay, various other methods are used for potency assessment of topical co...

The clinical problem Atopic eczema affects many adults and up to 20% of children,1 with health costs comparable to diabetes2 and asthma.3 One community survey of 1760 young children in the United Kingdom found that 84% had mild eczema, 14% moderate, and 2% severe eczema.4 Topical corticosteroids are a mainstay of treatment for inflammatory episodes.5 Most long established topical corticosteroid...