Surgical procedures are inevitably associated with bleeding. The amount of blood loss may vary widely between different surgical procedures and depends on surgical as well as non-surgical factors. Whereas adequate surgical haemostasis may suffice in most patients, pro-haemostatic pharmacological agents may be of additional benefit in patients with (diffuse) surgical bleeding or in patients with...

Background: Many surgical haemostatic agents are available which aim to reduce morbidity and mortality of bleeding, as well as associated costs. We used qualitative techniques to compare the effectiveness of two topical gelatine-based haemostatic agents in a porcine liver trauma model. Methods: We compared the activity of Floseal (with human or bovine thrombin), Surgiflo and Surgiflo plus 5000 ...

BACKGROUND Flowable haemostatic agents have been shown to be superior to non-flowable agents in terms of haemostatic control and need for transfusion products in patients undergoing cardiac surgery. We investigated the economic impact of the use of a flowable haemostatic agent (Floseal) compared with non-flowable oxidised regenerated cellulose (ORC) agent in primary elective cardiac surgery fro...

background: in modern life, the incidence of traumatic injuries increases daily. in accidents which lead to trauma, massive bleeding is the main cause of death. nowadays, many different chemical and herbal agents are available for quick control of bleeding. objectives: in this study, we compare the effectiveness of two different types of chemical agents for control of bleeding in an animal mode...

Many patients present with wounds which are bleeding or prone to bleeding, and so cannot be treated with a noninteractive dressing. These wounds include: 8 Partialand full-thickness wounds 8 Arterial and venous ulcers 8 Diabetic foot ulcers 8 Pressure ulcers 8 Fungating lesions 8 Post-surgical wounds 8 Toe nail avulsions 8 Donor sites 8 Traumatic wounds 8 Wounds post debridement (sharp, surgica...

Skilful surgery combined with blood-saving methods and careful management of blood coagulation will all help reduce unnecessary blood loss and transfusion requirements. Excessive surgical bleeding causes hypovolaemia, haemodynamic instability, anaemia and reduced oxygen delivery to tissues, with a subsequent increase in postoperative morbidity and mortality. The role of anaesthetists in managin...

The use of plasma-derived and recombinant coagulation factors for the treatment of haemophilia A and B is well established and permits patients to live a relatively normal life. In order to improve treatment options, several products are in development, which have a prolonged duration of action, thus enabling less frequent prophylactic dosing and aiming to reduce the burden of treatment. Severa...

AIM To compare the haemostatic effect and tissue reactions of different agents and methods used for haemorrhage control in apical surgery. METHODOLOGY Six standardized bone defects were prepared in the calvaria of six Burgundy rabbits. Five haemostatic modalities were tested for their haemostatic effect and tissue reactions, and were compared with untreated control defects: Expasyl + Stasis, ...