A six year-old girl presented with a facial rash first noted for two months (Figure 1). She had a known personal and family history of atopy with mild eczema affecting distal limbs and trunk treated with on occasional use of mild topical corticosteroid. The facial lesion was mildly itchy and worsened despite emollient cream and topical corticosteroid cream given for one month by her family doctor.

In 50 healthy Peruvian shantytown residents, zinc cream applied to tuberculosis skin-test sites caused a 32% increase in induration compared with placebo cream. Persons with lower plasma zinc had smaller skin-test reactions and greater augmentation with zinc cream. Zinc deficiency caused false-negative skin-test results, and topical zinc supplementation augmented antimycobacterial immune respon...

Mometasone furoate, a potent glucocorticoid (class III) with a favorable benefit/risk ratio, has emerged as a standard medication for the treatment of inflammatory skin disorders. The purpose of the investigation presented here was to determine the noninferiority of a topical mometasone formulation, a light cream (O/W 60/40 emulsion) with mometasone furoate 0.1% (water content of 33%) versus ma...

Tretinoin is the most effective available topical comedolytic agent, but topical application may lead to erythema, peeling and burning of the skin. During the past few decades many reports have documented an emergence of antibiotic resistance by Propionibacterium acnes during treatment of acne. Furthermore, systemic antimicrobials used in the treatment of acne have been causally associated with...

BACKGROUND This two-arm, randomized clinical study aimed to compare efficacy between topical Alpha ointment and topical hydrocortisone cream (1%) in the healing of radiation-induced dermatitis in breast cancer patients. METHODS The inclusion criteria comprised newly pathologically proven, locally advanced breast cancer (treated with modified radical mastectomy followed by sequential adjuvant ...

CT: computerized tomography OSCC: oral squamous cell carcinoma RMT: retromolar trigone INTRODUCTION Oral squamous cell carcinoma (OSCC) has historically been treated with surgery or radiation with or without chemotherapy, all of which lead to significant posttreatment morbidity. Topical imiquimod cream has been approved by the Food and Drug Administration for treatment of nonhyperkeratotic acti...

BACKGROUND The chronic and relapsing nature of vulvar lichen sclerosus (VLS) represents a challenge for its long-term management after an effective treatment with topical corticosteroids. OBJECTIVES To assess the effectiveness of proactive, twice-weekly application of mometasone furoate 0·1% ointment, compared with daily topical vitamin E or cold cream, in keeping VLS in remission and reducin...

BACKGROUND A variety of topical anesthetic compounds are available for use prior to minimally or moderately painful cutaneous laser procedures. A novel lidocaine/tetracaine-based peel has recently been developed that is applied to the skin as a cream and, once air dried, is removed as a flexible film that may prove useful in providing adequate dermal anesthesia for dermatologic laser surgery. ...

BACKGROUND Transient hyperpigmentation is the most common complication seen following cutaneous carbon dioxide (CO2) laser resurfacing. OBJECTIVE The purpose of this study was to determine whether the use of a topical skin lightening regimen prior to cutaneous laser resurfacing reduces the incidence of post-laser resurfacing hyperpigmentation. METHODS One hundred consecutive CO2 laser resur...