It has been known that the sparse approximate inverse preconditioning procedures SPAI and PSAI(tol) are costly to construct preconditioners for a large sparse nonsymmetric linear system with the coefficient matrix having at least one relatively dense column. This is also true for SPAI and the recently proposed sparse approximate inverse preconditioning procedure RSAI(tol) procedure when the mat...

Recent research on the acute effects of volatile organic compounds suggests that extrapolation from short (∼1 h) to long durations (up to 4 h) may be improved by using estimates of brain toluene concentration (Br[Tol]) instead of cumulative inhaled dose (C × t) as a metric of dose. This study compared predictions of these two dose metrics on the acute behavioral effects of inhaled toluene in ra...

Over the past century, solid organ transplantation has been improved both at a surgical and postoperative level. However, despite the improvement in efficiency, safety, and survival, we are still far from obtaining full acceptance of all kinds of allograft in the absence of concomitant treatments. Today, transplanted patients are treated with immunosuppressive drugs (IS) to minimize immunologic...

To maintain cellular structure and integrity during division, Gram-negative bacteria must carefully coordinate constriction of a tripartite cell envelope of inner membrane, peptidoglycan (PG), and outer membrane (OM). It has remained enigmatic how this is accomplished. Here, we show that envelope machines facilitating septal PG synthesis (PBP1B-LpoB complex) and OM constriction (Tol system) are...

This study demonstrates that ΔlogP(oct-tol) (difference between logP(octanol) and logP(toluene)) describes compounds propensity to form intramolecular hydrogen bonds (IMHB) and may be considered a privileged molecular descriptor for use in drug discovery and for prediction of IMHB in drug candidates. We identified experimental protocols for acquiring reliable ΔlogP(oct-tol) values on a set of c...

We present new VLA C-configuration H i imaging of the Lyα-emitting starburst galaxies Tol 1924−416 and IRAS08339+6517. The effective resolution probes neutral gas structures larger than 4.7 kpc in Tol 1924−416, and larger than 8.1 kpc in IRAS08339+6517. Both systems are revealed to be tidally interacting: Tol 1924−416 with ESO338−IG04B (6.6 = 72 kpc minimum separation), and IRAS08339+6517 with ...

The relationship between executive function and comorbid diagnoses in ADHD children is examined. One hundred six children between 7 and 15 years of age are assessed using the Tower of London (TOL), a test of executive function, and the Kiddie Schedule of Affective Disorders and Schizophrenia, Present and Lifetime Version, a diagnostic interview. All children met the diagnostic criteria for ADHD...

The tree of life (ToL) is used variously as metaphor, model, and research tool to explore life’s evolution and genealogical relationships. It has broad appeal for multiple scientific communities and the public as a descriptive term covering life’s diversity. However, as biologists identify more entities and events to describe—including species, organisms, cells, genomes, gene families, extra-ch...

The upper operon of the TOL plasmid pWW0 of Pseudomonas putida encodes a set of enzymes involved in the conversion of toluene and xylenes to their carboxylic acid derivatives. The last gene of the upper operon, xylN, encodes a 465-amino-acid polypeptide which exhibits significant sequence similarity to FadL, an outer membrane protein involved in fatty acid transport in Escherichia coli. To anal...

Discourses can be stronger than facts and, therefore, harder to dismantle. For example, the extinction of Selk’nam is a fallacy that has remained for more century since it was decreed by scientific community itself, thus making their descendants invisible. Combining this invisibility with peatlands - original habitat project seeks dismantle these discourses reusing and resignifying same ninet...