Immune responses to trinitrophenylated hemocyanin (TNP-KLH), Ficoll (TNP-Ficoll), and Brucella abortus (TNP-BA) were examined in BALB/c mice bearing subcutaneous transplants of TEPC-1017 and TEPC-1033, the two known IgD-secreting BALB/c plasmacytomas. Both primary and secondary 19S and 7S splenic plaque-forming cell (PFC) responses in spleen to intravenously injected TNP-KLH were enhanced three...

PURPOSE To determine the efficacy of the angiogenic inhibitor TNP-470 on inflammatory corneal neovascularization. Topical and systemic delivery of the drug were investigated in a murine model as well as inhibition of endothelial cell proliferation in vitro and in vivo. METHODS The effect of TNP-470 on VEGF- and bFGF-stimulated bovine capillary endothelial (BCE) cell proliferation was evaluate...

Transformer-less (TL) inverter topologies have elicited further special treatment in photo-voltaic (PV) power system as they provide high efficiency and low cost. Neutral point clamped (NPC) multilevel-inverter (MLI) topologies-based transformer-less are being immensely used grid-connected medium-voltage high-power claims. Unfortunately, these such NPC-MLI, full-bridge with DC bypass (FB-DCBP) ...

It has recently been shown that an idiotypic determinant(s) (460-Id) 1 found on the 2,4-dinitrophenyl (DNP) and 2,4,6-trinitrophenyl (TNP)-binding myeloma protein, MOPC-460, is expressed on some anti-TNP antibodies produced by BALB/c mice after immunization with certain thymus-independent (TI) (1) and thymus-dependent (2) TNP antigens. In vitro studies indicate that the 460-Id-bearing component...

Overexpression of the Tn5 transposase (Tnp) was found to be lethal to Escherichia coli. This killing was not caused by transposition or dependent on the transpositional or DNA binding competence of Tnp. Instead, it was strictly correlated with the presence of a wild-type N terminus. Deletions removing just two N-terminal amino acids of Tnp resulted in partial suppression of this effect, and del...

The potential metabolic drug interactions between TNP-470, a potent inhibitor of angiogenesis, and several commonly used anticancer agents, such as cyclophosphamide, taxol, and minocycline, were investigated in vitro using primary cultured hepatocytes and microsomes of rhesus monkeys. After incubation of hepatocytes with 5 microM [3H]TNP-470, rapid and extensive formation of six metabolites was...

Anaplastic thyroid carcinoma is an aggressive form of cancer with no treatment. Angiogenesis inhibitors, such as TNP-470, a synthetic derivative of fumagillin, have been shown to reduce tumor size and increase survival in heterotopic animal models of thyroid cancer. Our goals were to determine the effect of TNP-470 on anaplastic thyroid cancer using an orthotopic murine model, to identify the m...

Con el objetivo de arribar a una mayor comprensión del Trastorno Narcisista la Personalidad (TNP), presente estudio se centra en análisis relación entre TNP y determinados Esquemas Maladaptativos Tempranos (EMTs) descriptos por J. Young. Para ello, cien mujeres bajo nivel socioeconómico provincia Buenos Aires (Argentina) fueron evaluadas con entrevista psiquiátrica SCID-II les administraron los...

Normal spleen cells cultured with TNP-modified syngeneic spleen cells fail to mount an anti-TNP PFC response to TNP-ficoll or TNP-red blood cells,but go on to generate cytotoxic T cells directed at hapten-modified H-2.These results suggest that hapten-modifeid spleen cells may differentially induce B-cell tolerance and T- (Ly 2,3) cell immunity. The differential response to modified self by lym...

The antibody response of BALB/c mice to trinitrophenyl (TNP)-levan or TNP-Nocardia water-soluble mitogen (NWSM) includes a small but significant fraction of antibodies which share idiotypes (Id) with the dinitrophenyl (DNP)- and TNP-binding myeloma protein MOPC-460. Active immunization of BALB/c mice with MOPC-460 or passive administration of anti-460-Id antibodies suppresses the 460-Id+ compon...