INTRODUCTION To describe the underlay tympanoplasty technique using an acellular dermal graft(AlloDerm) for tympanic membrane (TM) reconstruction in a guinea pig model and to demonstrate the feasibility of the technique using AlloDerm tissue harvested from the prepuce as a source of tissue for future grafting in human TM reconstruction. MATERIALS AND METHODS The prepuce was divided during cir...

OBJECTIVE Thrombomodulin (TM), a glycoprotein constitutively expressed in the endothelium, is well known for its anticoagulant and anti-inflammatory properties. Paradoxically, we recently found that monocytic membrane-bound TM (ie, endogenous TM expression in monocytes) triggers lipopolysaccharide- and gram-negative bacteria-induced inflammatory responses. However, the significance of membrane-...

Traditional medicine (TM) is being used more frequently all over the world. However most often these are choices made by the patient. Integrating TM into mainstream health care would require research to understand the efficacy, safety, and mechanism of action of TM systems. This paper describes research done on TM and difficulties encountered in researching TM, especially when an attempt is mad...

Transactional memory (TM) is a promising lock-free synchronisation technique which offers a high-level abstract parallel programming model for future chip multiprocessor (CMP) systems. Moreover, it adapts the well established popular paradigm of transactions and thus provides a general and flexible way to allow programs to read and modify disparate memory locations atomically as a single operat...

Calcium activation of striated muscle is known to exhibit a strongly cooperative dependency on calcium. Because the calcium receptor protein, troponin (Tn) is known to bind calcium non-cooperatively and has yet to be linked to a cooperative change in the myosin-blocking protein, tropomyosin (Tm), we describe a model in which cooperativity is exclusively a myosin-dependent mechanism. The model c...

The trust plays an extremely important role in online shopping. In order to make online shopping trusty, this paper puts foreword a new trust model in e-commerce environment GIR-TM (Groups’ Internal Recommendation Trust Model). First, it regarded the network as a combination of groups, and then did the internal recommendation based on these groups. The GIR-TM, in the process of recommendation, ...

Integrins are transmembrane receptors composed of α and β subunits. Although most integrins contain β1, canonical activation mechanisms are based on studies of the platelet integrin, αIIbβ3. Its inactive conformation is characterized by the association of the αIIb transmembrane and cytosolic domain (TM/CT) with a tilted β3 TM/CT that leads to activation when disrupted. We show significant struc...

We have developed TM-align, a new algorithm to identify the best structural alignment between protein pairs that combines the TM-score rotation matrix and Dynamic Programming (DP). The algorithm is approximately 4 times faster than CE and 20 times faster than DALI and SAL. On average, the resulting structure alignments have higher accuracy and coverage than those provided by these most often-us...