During cancer metastasis, circulating tumor cells constantly experience hemodynamic shear stress in the circulation. Cellular responses to shear stress including cell viability and proliferation thus play critical roles in cancer metastasis. Here, we developed a microfluidic approach to establish a circulatory microenvironment and studied circulating human colon cancer HCT116 cells in response ...

conclusion results reinforced the pivotal role of vascular geometry, with respect to hemodynamics, together with the importance of performing patient-specific cfd analyses, through which the effect of different blood flow conditions on the aneurysm hemodynamics could be evaluated. objectives this study aimed to investigate the effects of variations in heart rate and internal carotid artery (ica...

BACKGROUND AND PURPOSE A recent randomized clinical trial on intracranial atherosclerosis was discontinued because of the higher frequency of stroke and death in the angioplasty and stent placement group than in the medical treatment group. An in-depth understanding of the relationship between biologic responses and flow dynamics is still required to identify the current limitations of intracra...

In this paper, we derive mathematical formulas for the skin friction coefficient in wall-bounded turbulence based on Reynolds averaged streamwise momentum equation and total stress. Specifically, with a theoretical or empirical relation of stress, is expressed terms mean velocity shear stress an arbitrary wall-normal region $$[h_0, h_1]$$ . The are validated using direct numerical simulation da...

BACKGROUND AND PURPOSE Little attention has been focused on the role of fluid-induced wall shear stress in fully developed cerebral aneurysms. The purpose of this study is to evaluate the alternation and distribution of wall shear stress over 1 cardiac cycle in patients' aneurysms. METHODS A middle cerebral artery aneurysm and a basilar tip aneurysm with localized outpouching (blebs) in their...

The purpose of this study was to determine the influence of radial motion of an arterial wall on the shear stress that flowing blood imposes on the wall (wall shear stress). Wall shear stress is known to influence endothelial cell function and may play a role in atherogenesis, but its magnitude and distribution in the circulation are not well understood. To simulate arterial wall motion, we use...

background: the interaction between the blood and the vessel wall is of great clinical interest in studying cardiovascular diseases, the major causes of death in developed countries. objective: to understand the effects of incorporating fluid-structure interaction into the simulation of blood flow through an anatomically realistic model of abdominal aorta and renal arteries reconstructed from c...

Myocardial contractility and blood flow provide essential mechanical cues for the morphogenesis of the heart. In general, endothelial cells change their migratory behavior in response to shear stress patterns, according to flow directionality. Here, we assessed the impact of shear stress patterns and flow directionality on the behavior of endocardial cells, the specialized endothelial cells of ...

The advent of microelectromechanical systems (MEMS) sensors has enabled real-time wall shear stress (WSS) measurements with high spatial and temporal resolution in a 3-D bifurcation model. To optimize intravascular shear stress assessment, we evaluated the feasibility of catheter/coaxial wire-based MEMS sensors in the abdominal aorta of the New Zealand white (NZW) rabbits. Theoretical and compu...

The development of wall shear stress in Görtler vortex flow was investigated by hot-wire measurements. The wavelengths of the vortices were pre-set by thin vertical perturbation wires so to produce the most amplified wavelengths. Three different vortex wavelengths of 12 mm, 15 mm, and 20 mm were considered, and near-wall velocity measurements were carried out to obtain the “linear” layers of ve...