HYPOTHESIS The detection of suspected malignant thyroid nodules by ultrasonography is associated with thyroid gland volume and tumor size. DESIGN Prospective clinical trial. SETTING A tertiary referral center. PATIENTS Three hundred sixty-five patients with a multinodular goiter with coexistent dominant nodules. MAIN OUTCOME MEASURES The correlation between thyroid gland volume and tumo...

Hyperfunctioning nodules of the thyroid are thought to only rarely harbor thyroid cancer, and thus are infrequently biopsied. Here, we present the case of a patient with a hyperfunctioning thyroid nodule harboring thyroid carcinoma and, using MEDLINE literature searches, set out to determine the prevalence of and characteristics of malignant "hot" nodules as a group. Historical, biochemical and...

Thyroid nodules are common. The clinical importance of thyroid nodules is related to excluding malignancy (4.0 to 6.5% of all thyroid nodules), evaluate their functional status and assess for the presence of pressure symptoms. Incidental thyroid nodules are being diagnosed with increasing frequency in the recent years with the use of newer and highly sensitive imaging techniques. The high preva...

Thyroid nodules are clinically palpable in 4-7% of adults in the United States. With ultrasound examination, thyroid nodules are identified in up to 70% of adults. In asymptomatic individuals, the potential for malignancy underlies the clinical importance of investigating thyroid nodules. Increased diagnostic accuracy has improved non-operative management of benign thyroid lesions. Appropriate ...

Thyroid nodules are a common problem found in up to two-thirds of the population on ultrasound examination. Nodules are often encountered incidentally on exams performed for other purposes. The prevalence increases with age and with radiation exposure and is higher amongst women. Approximately 5-15% of nodules are malignant; therefore, deciphering which nodules warrant attention is important. F...

Thyroid nodules are common findings in clinical practice and occur in more than 50% of adult population; nevertheless, only 7% of thyroid nodules are malignant. The aim of this study were to assess the value of ultrasound [US] in the detection of nodules, to characterize the thyroid nodules patterns by ultrasound and to differentiate between benign and malignant nodules. A total of 120 patients...

Because benign-appearing thyroid nodules with metastasis are very rare, the author reports herein four thyroid nodules (one follicular adenoma and three adenomatous nodules) with brain metastasis. A 75-year-old Japanese woman was admitted to our hospital because of thyroid mass. Imaging modalities revealed four distinct nodules in the thyroid, and tumorectomies of all nodules were performed und...

OBJECTIVE To study the clinical presentation, thyroid function tests, ultrasound (US) features, cytology and surgical pathology results of patients undergoing fine needle aspiration (FNA) biopsy of thyroid nodules and to determine if a significant difference exists in the above variables between small (less than 1 cm) and large (1 cm or more) thyroid nodules. METHODS The study is a retrospect...

Autonomously functioning thyroid nodules are characterized by an increased proliferation and function, which is predominantly caused by constitutively activating TSH receptor mutations leading to an activation of cAMP. In contrast to autonomously functioning thyroid nodules, cold thyroid nodules are functionally inactive and less differentiated. Their molecular cause is still unknown. To furthe...