Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cells is mainly regulated by TSH and by the intracellular concentration of I-. High doses of I- for 1 or 2 days inhibit the synthesis of thyroid hormones, a process known as the Wolff-Chaikoff effect....

Radioiodine uptake is not commonly seen by the thymus gland. On the contrary, the gland is slowly replaced by fat after puberty. Herein, we present 2 patients with papillary thyroid carcinoma, follicular variant, and cervical lymph node involvement. After total/near-total thyroidectomy, the patients received I for ablation therapy. On posttreatment radioiodine scintigraphy, mediastinal I uptake...

Iodide (I-) is an essential constituent of the thyroid hormones triiodothyronine (T3) and thyroxine (T4), and the iodide concentrating mechanism of the thyroid gland is essential for the synthesis of these hormones. In addition, differential uptake of iodine isotopes (radioiodine) is a key modality for the diagnosis and therapy of thyroid cancer. The sodium dependent iodide transport activity o...

The role of sympathetic innervation in regulation of thyroid function is incompletely understood. We, therefore, carried out studies in rats utilizing techniques of norepinephrine turnover to assess thyroid sympathetic activity in vivo. Thyroidal sympathetic activity was increased 95% by exposure to cold (4 degrees C), 42% by chronic ingestion of an iodine-deficient diet, and 32% in rats fed a ...

The vitamin A uptake cells in the anterior pituitary, thyroid gland, and pancreas of Japanese quails, coturnix coturnix japonica, were examined by the use of Sudan III staining, toluidine blue staining, fluorescence microscopy and electron microscopy. After excess vitamin A administration, most of interstitial cells, corresponding to fibroblasts, increased markedly the size and number of lipid ...

Introduction: Laryngeal squamous cell carcinoma (SCC) can invade the thyroid gland leading to unnecessary thyroidectomies with subsequent hypothyroidism and hyperparathyroidism. Thus, clinicopathological variables should be defined in order to predict thyroid gland invasion preoperatively.   Materials and Methods: We performed a retrospective analysis of 1,465 patients with laryngeal SCC referr...

we report a 75 year - old man who presented with a cervical mass, dysphagia anil hoarseness, ct - xcan of neck showed a large cold nodule in the right lobe of thyroid gland, which was followed by surgical excision and its histopathologic exam revealed well-differentiated chondrosarcoma.

Thyroid function is known to be affected by many commonly used drugs of varied chemical structures. It is known that substances like sulphonamides, perchlorates, nitrates affect thyroid activity. With the introduction of radio active iodine in experimental and clinical medicine, it has been possible to study critically the effect of drugs on thyroid activity, on the ba-is of iodine uptake by th...

introduction: 18f-choline pet-ct is an increasingly used technique in patients with prostate cancer. the main indication is to localise the disease in patients with biochemical recurrence. to accurately interpret 18f-choline pet, knowledge of normal tracer distribution is paramount. the aim of this study was to describe the normal distribution pattern of 18f-choline by measuring the maximum sta...

BACKGROUND Primary thyroid lymphoma is an uncommon neoplasm frequently associated with lymphocytic thyroiditis (LT). Once the pathologic diagnosis of primary thyroid lymphoma is established, imaging plays an important role in tumor staging and evaluating treatment response. The present case discusses the role of fluorodeoxyglucose positron emission tomography (18F-FDG PET)/computed tomography (...