Imaging of thyroid dysfunction is safe and clinically relevant in children. In congenital hypothyroidism (CH), thyroid imaging permits a precise characterization of the aetiology, which is important for genetic counselling and clinical management. CH may be due to thyroid dysgenesis (ectopia, hypoplasia and athyrosis) or occurs in eutopic glands. In the latter, hypothyroidism may be either tran...

It was aimed to evaluate the national congenital hypothyroidism program in terms of thyroid-stimulating hormone (TSH) cut-off level, frequency of cases that required treatment and the stages before treatment in the Kocaeli district area. This research was performed with the contribution of Kocaeli University Medical Faculty, Pediatric Endocrinology Department, and the Kocaeli Local Health Distr...

Three genes, TTF1, TTF2, and PAX8, involved in thyroid gland development and migration have been identified. Yet systematic screening for defects in these genes in thyroid dysgenesis gave essentially negative results. In particular, no TTF1 gene defects were found in 76 individuals with thyroid dysgenesis even though a deletion of this gene in the mouse results in thyroid and lung agenesis and ...

Thyroid hemiagenesis is a rare form of thyroid dysgenesis characterized by an absence of half of the thyroid gland. Developmental hemi-thyroid anomalies can result from either an abnormal descent or an agenesis of one lobe of the thyroid gland. We report a case of a 40-year-old woman with history of a longstanding gradually progressive thyroid swelling without any complication. An ultrasonograp...

Congenital Hypothyroidism (CH) is a common preventable cause of mental retardation. The incidence CH 1 in 2500 to 3000 newborns. Most causes are thyroid dysgenesis and dyshormonogenesis. Some disorder like maternal autoantibodies, intake anti medication, iodine deficiency or excess can result transient CH. Common symptoms include decreased activity increased sleep, feeding difficulty, constipat...

Congenital hypothyroidism, defined as the functional deficiency of thyroid hormones present at birth, is the most frequent endocrine disorder in pediatric patients with an incidence estimated in 1:2,0004,000 newborns. Significantly, iodide deficiency still remains as the leading cause of hypothyroidism at birth [1]. However, in iodidesufficient countries, a number of recent studies indicates th...

Background: Interspecific hybrid male sterility is a common occurrence in nature and plays vital role species reproductive isolation. Recently several studies have suggested decline the quality of semen. About half infertile causes are men; rate increases couples. Some therapy for sterility; medication, surgery, or assisted technology (ART). Medicinal effects not expected, surgical cases locali...

OBJECTIVE Developmental defects of the thyroid gland are the most frequent causes of permanent congenital hypothyroidism. This study aimed to investigate the epidemiological features of patients with thyroid dysgenesis (TD). METHODS Medical records of 234 patients with TD followed between the years 2008 and 2010 were evaluated retrospectively. Diagnosis was made by ultrasonography. RESULTS ...