A comparison is made of tests for thyroglobulin antibody, using gel diffusion, electroprecipitin, bentonite flocculation, tanned red cell agglutination, and latex slide agglutination techniques on sera from cases of Hashimoto's disease and other thyroid disorders. Any increase in gamma globulin was also noted from the serum electrophoretic pattern. The gel diffusion and electroprecipitin tests ...

BACKGROUND The development of antibodies to thyroid peroxidase, thyroglobulin, and thyroid-stimulating hormone (TSH) receptor is a main feature of autoimmune thyroid diseases. OBJECTIVE To investigate whether complete removal of thyroid antigens results in the abatement of humoral thyroid autoimmunity. DESIGN Retrospective chart review study of patients treated and monitored with a standard...

Ca2+-dependent neutral proteases in hog thyroid cytosol were found to digest thyroglobulin. The protease activity was divided into two peaks by DEAE-cellulose column chromatography. Peak I was eluted at 0.2 M NaCl and required only a micromolar range of Ca2+ for its 50% activation, while peak II, which was eluted at about 0.4 M NaCl, displayed little activity until the Ca2+ concentration was in...

AIMS Strong thyroglobulin immunoreactivity within sinus histiocytes in a lymph node draining a papillary thyroid carcinoma was observed in a recent case. This prompted the investigation of whether thyroglobulin immunoreactivity is common in regional lymph nodes in cases of thyroid malignancy. METHODS Eighty seven lymph nodes were studied from 21 cases of thyroid malignancy. These comprised pa...

Background: Abortion is the interruption and/or termination of pregnancy, either spontaneously or intentionally, before fetus develops sufficiently to survive. About 80% abortions occur in first 12 weeks pregnancy. The underlying mechanism about half cases involves chromosomal abnormalities. Objective: To evaluate association between TSH, T3, T4, anti-thyroglobulin antibody and thyroid peroxida...

Destruction-induced thyrotoxicosis includes various painful diseases such as subacute granulomatous thyroiditis, acute exacerbation of chronic thyroiditis and acute suppurative thyroiditis. In contrast, the clinically painless form of destruction-induced thyrotoxicosis is almost exclusively restricted to painless or silent thyroiditis. We report what we believe to be a case of acute exacerbatio...